急性脑梗死诱发全身炎症反应综合征患者血清C-反应蛋白和补体C3、C4水平变化

目的 探讨血清C-反应蛋白(CRP)和补体C3、C4在急性脑梗死(ACI)诱发全身炎症反应综合征(SIRS)发生中的作用.方法 应用全自动免疫比浊定量分析法分别测定52例ACI致SIRS患者(SIRS组)、50例急性单纯ACI患者(SACI组)及46例正常对照组血清CRP和补体C3、C4含量.结果 血清CRP和补体C3、C4含量在3组间比较,差异均具有统计学意义(F值分别为720.6、580.8和94.1,P均<0.01).SIRS组血清CRP水平高于SACI组(P<0.01),血清补体C3、C4均低于SACI组(P均<0.01).血清CRP含量随符合SIRS诊断标准数目的 增多而升高(t=7.69,P<0.01),补体C3、C4含量则随符合SIRS诊断标准数目的 增多而下降(t值分别为10.68和10.53,P均<0.01).结论 ACI进展为SIRS后,血清CRP明显升高,补体C3、C4明显下降,血清CRP和补体C3、C4可作为判断病情进展为SIRS的一项指标.

Clinical study of serum C-reactive protein,supplement C3 and C4 in the patients with systemic inflammatory response syndrome induced by acute cerebral infarction

Objective To study the role of serum C-reactive protein (CRP) ,supplement C3 and CA in sys-temic inflammatory response syndrome (SIRS) induced by acute cerebral infarction(ACI).Methods The levels of CRP,C3 and CA were measured by automatic immunoturbidimetry in 52 ACI cases accompanied with SIRS (SIRS group) ,50 cases of acute simple cerebral infarction(SACI group) and 46 normal cases (control group).Results The serum CRP, C3 ,and CA levels were significantly different among the three groups( F=720.6,580.8,94.1 ,P <0.01) ,the serum CRP levels in SIRS group were significantly higher than those in SACI group(P <0.01 ).The ser-um C3 and CA levels in SIRS were significantly lower than those in SACI group(P <0.01).With the diagnosis crite-rion items increasing, the serum CRP levels tended to be higher (t = 7.69 ,P < 0.01 ), and the serum C3, CA levels tended to be lower meeting SIRS diagnosis criterion numbers increasing respectively (t=10.68 and 10.53, P <0.01).Conclusion The serum ClIP levels are higher significantly and the serum levels of C3 and C4 are lower sig-nificantly when ACI progresses to SIRS.The serum CRP,C3,CA level changes can be used as an index for judging the progress of ACI progressed to SIRS.