| The Role of sICAM-1 Detection in the Diagnosis of Acute Rejection Following Liver Transplantation |
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| 引用本文： | 俞亚红,陈忠,叶启发. The Role of sICAM-1 Detection in the Diagnosis of Acute Rejection Following Liver Transplantation[J]. 华中科技大学学报(医学英德文版), 2006, 26(5): 580-582. DOI: 10.1007/s11596-006-0526-3 |
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| 作者姓名： | 俞亚红 陈忠 叶启发 |
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| 作者单位： | [1].Department of General Surgery, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [2]Institute of Xiangya Transplantation Medicine, Xiangya Third Hospital, China South University, Changsha 410013, China |
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| 摘 要： | In order to evaluate the applied value of soluble intracellular adhesion molecule-1 （sICAM-l） in acute rejection （AR） following liver transplantation, the expression of sICAM-1 protein was sequentially detected by using ELISA in serum and bile of 43 patients receiving liver transplantation. In AR group, the expression levels of sICAM-1 protein were increased 3 days before and immediately on the establishment of AR diagnosis, and there was significant difference in the expression of bile between AR group and control group （P〈0.01）. After reversion of AR with hormone intensive therapy, there was significant difference in the sICAM-1 protein expression of serum and bile between AR group and control group. It was concluded that the sequential detection of sICAM-1 protein level in serum and bile was a reliable and noninvasive method for the early diagnosis of AR after liver transplantation and was valuable to observe the curative effects of anti-AR therapy.
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| 关 键 词： | 肝移植 诊断方法 胆汁 血清 |
| 收稿时间： | 2006-07-17 |
The role of sICAM-1 detection in the diagnosis of acute rejection following liver transplantation |
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| Yahong Yu M.D., Ph.D.,Zhong Chen,Qifa Ye. The role of sICAM-1 detection in the diagnosis of acute rejection following liver transplantation[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2006, 26(5): 580-582. DOI: 10.1007/s11596-006-0526-3 |
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| Authors: | Yahong Yu M.D. Ph.D. Zhong Chen Qifa Ye |
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| Affiliation: | 1. Department of General Surgery, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2. Institute of Xiangya Transplantation Medicine, Xiangya Third Hospital, China South University, Changsha 410013, China |
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| Abstract: | In order to evaluate the applied value of soluble intracellular adhesion molecule-1 (sI-CAM-1) in acute rejection (AR) following liver transplantation, the expression of sICAM-1 protein was sequentially detected by using ELIS A in serum and bile of 43 patients receiving liver transplantation. In AR group, the expression levels of sICAM-1 protein were increased 3 days before and immediately on the establishment of AR diagnosis, and there was significant difference in the expression of bile between AR group and control group (P<0.01). After reversion of AR with hormone intensive therapy, there was significant difference in the sICAM-1 protein expression of serum and bile between AR group and control group. It was concluded that the sequential detection of sICAM-1 protein level in serum and bile was a reliable and noninvasive method for the early diagnosis of AR after liver transplantation and was valuable to observe the curative effects of anti-AR therapy. |
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| Keywords: | orthotopic liver transplantation acute rejection bile serum sICAM-1 |
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