口腔颌面外科患者手术前后甲状腺激素水平的变化

目的:观察口腔颌面外科不同程度手术创伤患者手术前、后甲状腺激素水平的改变,为术后康复治疗提供参考依据。方法:利用放射免疫方法检测60例口腔颌面手术患者(局麻小手术患者30例,全麻手术患者30例)术前及术后第1、4、7天血清中促甲状腺激素(TSH)、甲状腺素(T4)、三碘甲状腺原氨酸(T3)、反-三碘甲状腺原氨酸(rT3)等激素水平的改变。采用SPSS10.0软件包对数据进行单因素方差分析。结果:与术前相比,口腔颌面外科全麻手术患者术后第1、4、7天的T3、T4、rT3水平下降有显著差异(Ρ<0.01),TSH亦显著下降(Ρ<0.05);而局麻小手术患者,术前与术后第1、4、7天的T3、T4、rT3、TSH水平下降均无显著差异(Ρ>0.05)。结论:手术创伤和麻醉种类与患者甲状腺激素水平高低有一定关系。

Thyroid hormone level change in patients undergoing oral and maxillofacial surgery

PURPOSE:To study the changes of thyroid hormone level in patients undergoing oral and maxillofacial surgery before and after operation,in order to provide some evidences for postoperative treatment and recovery.METHODS:60 cases with oral and maxillofacial operations under general or local anesthesia were assayed by radioimmunoassay for hormone levels changes of T3,T4,r T3 and TSH in serum before operation and on the first,forth and seventh day after operation.SPSS10.0 software package was used for one way ANOVA.RESULTS:Compared to preoperative levels,T3,T4 and r T3(P<0.01)as well as TSH(P<0.05)in patients receiving operations under general anesthesia on the first,forth and seventh day postoperatively decreased significantly,while the changes of thyroid hormone level in patients receiving operations under local anesthesia before and after operation were not significantly different.CONCLUSION:Thyroid hormone level change in patients who underwent oral and maxillofacial surgery may be related to the type of operation and anesthesia.