VEGF-PET imaging is a noninvasive biomarker showing differential changes in the tumor during sunitinib treatment |
| |
| Authors: | Nagengast Wouter B Lub-de Hooge Marjolijn N Oosting Sjoukje F den Dunnen Wilfred F A Warnders Frank-Jan Brouwers Adrienne H de Jong Johan R Price Patricia M Hollema Harry Hospers Geke A P Elsinga Philip H Hesselink Jan Willem Gietema Jourik A de Vries Elisabeth G E |
| |
| Institution: | Department of Medical Oncology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands. |
| |
| Abstract: | Non-invasive imaging of angiogenesis could ease the optimization of antiangiogenesis treatments for cancer. In this study, we evaluated the role of VEGF-PET as a biomarker of dynamic angiogenic changes in tumors following treatment with the kinase inhibitor sunitinib. The effects of sunitinib treatment and withdrawal on the tumor was investigated using the new VEGF-PET tracer (89)Zr-ranibizumab as well as (18)F-FDG PET, and (15)O-water PET in mouse xenograft models of human cancer. The obtained imaging results were compared with tumor growth, VEGF plasma levels and immunohistologic analyzes. In contrast to (18)F-FDG and (15)O-water PET, VEGF-PET demonstrated dynamic changes during sunitinib treatment within the tumor with a strong decline in signal in the tumor center and only minimal reduction in tumor rim, with a pronounced rebound after sunitinib discontinuation. VEGF-PET results corresponded with tumor growth and immunohistochemical vascular- and tumor- markers. Our findings highlight the strengths of VEGF-PET imaging to allow serial analysis of angiogenic changes in different areas within a tumor. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
