白细胞介素8、弹性蛋白酶与中、重度慢性牙周炎临床指标的相关性

目的:探讨中、重度慢性牙周炎患者龈沟液中白细胞介素8(IL-8)及细胞内、外弹性蛋白酶浓度与临床指标的相关性。方法:检查30名中、重度慢性牙周炎患者初诊和治疗后1个月的牙周临床指标,并检测其龈沟液中IL-8及细胞内、外弹性蛋白酶浓度,以20名牙周健康者作为对照。结果:患病组细胞外弹性蛋白酶浓度显著高于健康对照组(P<0.01)。慢性牙周炎患者龈沟液中细胞外弹性蛋白酶浓度与牙周袋深度、牙周附着丧失呈显著正相关(P<0.01),细胞内、外弹性蛋白酶浓度与牙龈指数呈显著正相关(P<0.01)。结论:细胞外弹性蛋白酶浓度较IL-8浓度更能够反映牙周袋内的炎症程度。

Correlation between the concentrations of interleukin-8 and elastase and the clinical indexes in patients with moderate to severe periodontitis

Objective:To explore the correlation between the concentrations of interleukin-8 (IL-8) and elastase in the gingival cervicular fluid (GCF) and the clinical indexes in patients with moderate to severe periodontitis. Methods: The periodontal indexes in 30 patients with periodontitis were detected with Florida probe at the baseline and 1 month after the treatment. The levels of IL-8,elastase in the supernatant (EA-s),and elastase in the pellet (EA-p) were measured in these 30 patients with peridontitis and 20 healthy controls. Results: The concentration of EA-s in patients with peridontitis was significantly higher than that in healthy controls. In patients with peridontitis,the concentration of EA-s in GCF was positively correlated with the periodontal pocket depth and attachment loss (P < 0.01),and the concentrations of EA-s and EA-p were positively correlated with gingival indexes (P < 0.01). Conclusion: The concentration of EA-s is more accurate than the concentration of IL-8 for indicating the inflammation of periodontal pocket.