广西壮族自治区1 816名健康人群跟骨超声骨密度测量

目的探讨广西壮族自治区健康人群跟骨超声骨密度与年龄、身高、体重等的关系,初步建立该地区健康人群跟骨超声硬度指数(SI)的正常参考值范围,为骨质疏松的诊断和预防提供科学依据。方法采用Achilles Express跟骨超声骨密度测定仪对广西地区1816名(男性775名、女性1041名)11~90岁健康志愿者进行跟骨SI测定。按不同性别,每5岁为1个年龄组,70岁以上合并为1组,男女各分为13组,对测量数据进行统计学分析。结果男女跟骨SI分别在21~25岁(111·45±21·19)和16~20岁(101·26±17·51)年龄组达到峰值,之后均随年龄而下降,女性呈现出典型的双峰特征;61岁以上女性的SI显著低于同年龄组男性(P<0·05)。多元线性逐步回归分析显示男女SI与年龄呈显著负相关(P<0·001);与体重呈显著正相关(男性P<0·05、女性P<0·01);女性SI与身高呈显著的正相关(P<0·01),但男性SI与身高无相关性。结论广西壮族自治区健康人群SI与年龄、身高、体重均有显著的相关性,本研究获得的SI值可为临床和流行病学研究中诊断骨质疏松症提供参考。

Ultrasonic bone mineral density of calcaneus in 1 816 healthy subjects in Guangxi autonomous region

OBJECTIVE: To study the relationship between ultrasonic bone mineral density (BMD) of calcaneus and age, height, and body weight, and to establish the normal reference value for stiffness index (SI) of healthy subjects in Guangxi autonomous region and provide scientific foundation for the diagnosis and prevention of osteoporosis. METHODS: SI of calcaneus in 1 816 healthy adults aged 11-90 years (775 men, 1 041 women) were measured with quantitative ultrasound. According to their ages, all the men and women were divided into 13 groups by 5-year age group. RESULTS: SI reached peak values in 21-25 year group in men (range: 111.45 +/- 21.19) and in 16-20 year group in women (range: 101.26 +/- 17.51). Then the SI value began to decline with aging. The SI featured by a typical dual-peak curve in women and the decrease rate of SI was faster in women than in men over 61 years. Multivariate linear regression analysis showed significantly negative correlation between SI and age (P < 0.001), positive correlation between SI and body weight (P < 0.05 for men; P < 0.01 for women), and positive correlation between SI and height in women (P < 0.01). CONCLUSION: SI correlates with age, height, and weight. The acquired SI value may provide a reference for the diagnosis of osteoporosis.