| 胃癌组织中P53和PTEN蛋白的表达 |
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| 引用本文： | 胡少为,张维彬,肖 刚,石灵春,吕 申.胃癌组织中P53和PTEN蛋白的表达[J].大连医科大学学报,2008,30(4):318-320. |
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| 作者姓名： | 胡少为 张维彬 肖 刚 石灵春 吕 申 |
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| 作者单位： | 1. 广东省中医院,病理科,广东,广州,510120
2. 大连医科大学附属第二医院,实验中心,辽宁,大连,116027 |
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| 摘 要： | 目的]检测胃癌组织中P53、PTEN蛋白的表达情况,进一步探讨它们在胃癌发生发展过程中的作用.方法]免疫组织化学方法检测胃癌、癌旁及胃炎组织中P53和PTEN蛋白表达情况.结果]P53蛋白在胃癌组织中的表达率为88.7%,明显高于胃炎(23,5%)及癌旁组织(11.3%)的表达率(P＜0.05).PTEN蛋白在胃癌组织的表达率为64.5%,明显低于胃炎组织的表达率(91.2%,P＜0.05).在55例P53蛋白表达的胃癌组织中,21例不表达PTEN蛋白;在7例P53蛋白表达阴性的胃癌组织中,仅1例不表达PTEN蛋白.结论]胃癌组织中P53蛋白表达上调,PTEN蛋白表达下调.
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| 关 键 词： | 胃癌 P53 PTEN |
P53 and PTEN protein expression in gastric carcinoma |
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| HU Shao-wei,ZHANG Wei-bin,XIAO Gang,SHI Ling-chun,LU Shen.P53 and PTEN protein expression in gastric carcinoma[J].Journal of Dalian Medical University,2008,30(4):318-320. |
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| Authors: | HU Shao-wei ZHANG Wei-bin XIAO Gang SHI Ling-chun LU Shen |
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| Institution: | 1.Department of Pathology;Traditional Chinese Medicine Hospital of Guangdong Province;Guangzhou 510120;China;2.The Second Affiliated Hospital of Dalian Medical University;Dalian 116027;China |
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| Abstract: | Objective] To detect the expression of P53 and PTEN proteins,in gastric carcinoma.Methods] The immunohistochemical method was used to examine the expression of P53 and PTEN proteins in gastric carcinoma,paratumorous lesions and gastritis.Results] The positive rate of P53 expression was 88.7% in gastric carcinoma,which was significantly higher than that in paratumorous lesions(11.3%) and gastritis(23.5%) respectively(P<0.05).The positive rate of PTEN expression was 64.5% in gastric carcinoma,which was sig... |
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| Keywords: | 胃癌 P53 FIEN |
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