| 茶碱指数衰减滴注及程序输注的研究 |
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| 引用本文： | 段世明,徐迅,黄卉芳,叶妙,付英.茶碱指数衰减滴注及程序输注的研究[J].中国药理学通报,1993(3). |
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| 作者姓名： | 段世明 徐迅 黄卉芳 叶妙 付英 |
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| 作者单位： | 徐州医学院麻醉药理教研室 徐州221002
(段世明，徐迅，黄卉芳，叶妙)，徐州医学院麻醉药理教研室 徐州221002(付英) |
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| 基金项目： | 江苏省省教委自然科学基金资助课题 |
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| 摘 要： | 用紫外分光光度计法测定兔血浆茶碱浓度.应用群体兔药代动力学参数进行恒速静脉滴注、指数衰减滴注及程序输注。结果:虽茶碱T_(1/2β)=6.08h,但指数衰减滴注及程序输注仅需30min即可达到预期血药稳态浓度。程序输注及指数衰减滴注的执行百分误的中位数分别为7.8％.14％。
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| 关 键 词： | 茶碱 指数衰减滴注 程序输注药物代谢 动力学 |
Studies on the exponentially declining infusion and the program infusion of theophyl ine in rabbits |
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| DUAN Shi-Ming,XU XUN,HUANG Hui-Fang.Studies on the exponentially declining infusion and the program infusion of theophyl ine in rabbits[J].Chinese Pharmacological Bulletin,1993(3). |
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| Authors: | DUAN Shi-Ming XU XUN HUANG Hui-Fang |
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| Abstract: | Constant infusion, exponentially declining infusion and program infusion of theophlline were administered to rabbits by
adopting the rabbit population pharmacokinetic parameters in this laboratory, and the plasma concentrations of the drug was measured by ul- traviolet spectrophotometry. The results showed that the plasma drug concentrations following exponentially declining infusion and program infusion attained the desired steady-state level at only 30 min, though the T1/2β= 6. 08h, The median absolute value of performance error in pro-
gram infusion and exponentially declining infusion was 7. 8% and 14% respectively. |
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| Keywords: | theophyline esponentially declining infusion program infusion pharmacoki-netics |
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