Once-Daily Fluticasone Propionate in Stable Asthma: Study on Airway Inflammation |
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Authors: | Albert M. Li Dr. Tony W. T. Tsang Karen Chan Dorothy F. Y. Chan Rita Y. T. Sung Tai F. Fok |
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Affiliation: | a Department of Pediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong |
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Abstract: | Children with stable asthma receiving twice-daily fluticasone propionate (FP) were studied. Spirometry, exhaled nitric oxide (eNO) and sputum eosinophils were measured at baseline and 8 weeks after FP was changed to once-daily use while keeping the same total dosage. Visual analogue scores on asthma severity, symptoms, and dosing regimen preference were obtained. Twenty-nine children of mean age 10.6 years (SD 2.5) were recruited. There was significant improvement in eNO (47.1 ppb [30.3] vs. 39.9 ppb [27.1], p = 0.037), and sputum eosinophils (5.7% [6.5] vs. 2.5% [3.9], p = 0.024] after 8 weeks. All subjects preferred the once-daily dosing regimen. Once-daily FP is effective in controlling airway inflammation. This frequency of medication use is also the preferred regimen. |
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Keywords: | fluticasone propionate asthma once-daily airway inflammation |
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