Binding of human lipoproteins (low, very low, high density lipoproteins) to recombinant envelope proteins of hepatitis C virus |
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Authors: | Masyar Monazahian Serena Kippenberger Anke Müller Holger Seitz Ingo Böhme Stefanie Grethe Reiner Thomssen |
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Institution: | Department of Virology, University of G?ttingen, Kreuzbergring 57, 37075, G?gottingen, Deutschland
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Abstract: | Heterogeneities in the density of hepatitis C virus (HCV)-RNA-carrying material from human sera (1.03–1.20 g/ml) are partially
due to the binding of lipoproteins low density (LDL), very low density (VLDL), high density (HDL) lipoproteins] and immunoglobulins.
In this study we demonstrate the binding of recombinant HCV envelope protein (E1/E2) to human LDL, VLDL and HDL on a molecular
basis. The binding of lipoproteins was restricted to the middle part of the E1 gene product (amino acids 222–336) and the
C-terminal part of the E2 protein (amino acids 523–809). Lipoproteins did not bind to recombinant HCV core protein.
Received: 22 December 1999 |
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Keywords: | Hepatitis C virus Lipoprotein Low very low high density lipoprotein Recombinant hepatitis C virus envelope protein Binding site |
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