序贯疗法与三联疗法根除幽门螺杆菌疗效对比研究

目的：比较序贯疗法与三联疗法根除幽门螺杆菌（H．pylori，Hp）的临床疗效。方法选择2013年10月-2014年3月新疆医科大学第一附属医院消化内科证实存在 Hp 感染需要治疗的新疆地区194例患者，随机分为两组：序贯疗法组（99例），前5天：埃索美拉唑肠溶片40 mg ＋阿莫西林分散片1000 mg，每日2次，后5天：埃索美拉唑肠溶片40 mg＋克拉霉素片500 mg＋呋喃唑酮片100 mg，每日2次。三联疗法组（94例）：埃索美拉唑肠溶片40 mg＋阿莫西林分散片1000 mg＋克拉霉素片500 mg，每日2次，疗程均10 d。比较两组患者 Hp 根除率、不良反应发生率。结果序贯疗法组及三联疗法组 Hp 根除率分别为87．88％、81．05％，差异有统计学意义（P ＝0．031）。两者组患者不良反应发生率分别为6．1％和8．4％，差异无统计学意义。患者在序贯疗法组中 Hp 根除率明显高于维吾尔族和其他少数民族，差异有统计学意义。结论在新疆地区，序贯疗法较三联疗法 Hp 根除率高，安全性相似。

The contrastive study on the clinical effect of Sequential therapy and tripal treatment for eradication of Helicobacter Pylori

Objective To compare the clinical effect of sequential therapy and tripal treatment for eradication of Helicobacter Pylori （Hp）.Methods 194 cases with Hp infection between October 2013 and March 2014 were selected from Department of Gastroenterology of the First Affiliated Hospital of Xinjiang Medical University.They were randomly divided into two groups：the sequential treatment group （99 ca-ses）and Triple therapy group （94 cases）.The patients in the sequential treatment group were given Es-omeprazole enteric soated tablets 40 mg＋Anoxicllin Dispersible Tablets 1 000 mg,twice a day in the first five days;and Esomeprazole enteric soated tablets40 mg＋Clarithromycin tablets 500 mg＋Furazolidone Tables 100 mg,Twice a day in the last five days.The patients in the triple therapy group were given Es-omeprazole enteric soated tablets 40 mg＋Anoxicllin Dispersible Tablets 1 000 mg＋Clarithromycin tablets 500 mg,twice a day,for 10 days as a course of treatment.Then we compared the rate of eradication and the incidence of adverse reactions or side effect between two groups.Results The rate of eradication of Hp in sequential therapy group and the triple therapy group was 87.88%,81.05%,and the difference was sta-tistically significant （P =0.031）.The incidence of adverse reactions in both groups was 6.1% and 8.4% re-spectively,and the difference was not statistically significant.In the sequential therapy group patients Hp eradication rate was significantly higher than that in the Uighur and other minorities,the difference was statistically significant.Conclusion The rate of eradication of H.Pylori in sequential treatment was higher than that in triple therapy in Xinjiang.The safety of two therapies is the same.