茵栀黄联合蓝光治疗新生儿高胆红素血症40例临床观察

目的:探讨茵栀黄联合蓝光治疗新生儿高胆红素血症的疗效。方法:将新生儿高胆红素血症80例分为治疗组(40例)和对照组(40例),对照组采用间隙蓝光照射,胆红素上升快或水平高者给予纠酸、肝酶诱导剂、白蛋白静脉滴注,对症及支持治疗,如供氧、抗感染、静脉营养、保持通便等常规治疗方法。治疗组在此基础上加用茵栀黄。两组治疗前查血清总胆红素,治疗期间,应用经皮胆红素监测仪,监测每天胆红素变化,同时监测血清胆红素值下降至正常的天数。结果:茵栀黄联合蓝光治疗组治疗前血清胆红素(310.60±20.53)μmol/L与对照组治疗前血清胆红素(298.37±17.13)μmol/L,比较两组无显著差异(P>0.05);茵栀黄联合蓝光治疗组治疗后胆红素值(78.52±14.59)μmol/L与对照组治疗后胆红素值(94.30±11.21)μmol/L比较两组差异有统计学意义(P<0.05);治疗组胆红素降至正常天数(5.32±2.37)d与对照组胆红素降至正常天数(7.12±2.33)d比较,两组差异均有统计学意义(P<0.05);茵栀黄联合蓝光治疗组总有效率90%,明显高于对照组总有效率75%,两组有效率差异有统计学意义(P<0.05)。结论:茵栀黄联合蓝光治疗新生儿高胆红素血症疗效肯定,值得临床推广。

Clinical observation on treating 40 cases of neonatal hyperbilirubinemia by Yinzhihuang combined with blue light

Objective： To investigate efficacy of Yinzhihuang combined with blue light in the treatment of neonatal hyperbilirubinemia. Methods： 80 cases of neonatal hyperbilirubinemia were divided into treatment group （40 cases） and control group （40 cases）. The control group used the gap blue light irradiation, bilirubin increases fast or high level to give correct acid, Liver enzyme inducer, albumin infusion, symptomatic and supportive treatment, such as oxygen offering, resistance to infection, intravenous nutrition, keep laxative and other conventional treatment methods. The treated group was treated with Yinzbihuang based on the routine treatment. The two groups before treatment examination of the serum total bilirubin. During treatment, the application of percutaneous bilirubin monitor, monitoring daily bilirubin changes, while monitoring the serum bilirubin values decreased to normal days. Results： Before treatment, the treatment group examination of the serum bilirubin values was （310.60 ±20.53） μmmol/L and the control group was （298.37 ±17.13） μmmol/L, there were not significantly differences between the two groups （P〉0.05）. After treatment, treated group examination of serum bilirubin values was （78.52±14.59） μmmol/L and the control group was （94.30±11.21） μmmol/L, the two group showed the statistically significant differences （P〈0.05）. The treated group bilirubin decreased to normal cost（5.32±2.37） days and the control group cost （7.12±2.33） days, the two group showed the statistically significant differences （P〈0.05）. The total efficiency of treated group was 90%, significantly higher than 75% of the control group, the differences of the total efficiency between two groups were statistically significant （P〈0.05）. Conclusion： Yinzhihuang combined with blue light has certain curative effect in the treatment of neonatal hyperbilirubinemia. It is worthy of clinical application.