Rare complications after second hematopoietic stem cell transplantation for thalassemia major |
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Authors: | Yanir Asaf Yatsiv Ido Braun Jacques Zilkha Amir Brooks Rebecca Bouhanna Dalia Weintraub Michael Stepensky Polina |
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Affiliation: | Department of Pediatrics, Hadassah Hebrew University Medical Center, Jerusalem, Israel. ayanir@hadassah.org.il |
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Abstract: | We describe an 11-year-old girl with thalassemia major who underwent a second hematopoietic stem cell transplantation from a matched related donor and who subsequently developed posttransplant lymphoproliferative disorder complicated by severe ascending paralysis resembling Guillian-Barré syndrome. Six months later she developed a massive pericardial effusion. She received a multimodal treatment for these complications and currently, 18 months after transplantation, she is in a good clinical condition, is transfusion independent, with no evidence of graft-versus-host disease and off all treatment. This case highlights the dilemma surrounding second hematopoietic stem cell transplantations in hemoglobinopathies and the need for a careful, well informed, and collaborative decision-making process by patients, families, and medical professionals. |
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