同型半胱氨酸诱导人血管平滑肌细胞氧化损伤的研究 |
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引用本文: | 苏娟,吴树人,吴建新,秦燕. 同型半胱氨酸诱导人血管平滑肌细胞氧化损伤的研究[J]. 中国实用医药, 2009, 4(8): 28-30 |
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作者姓名: | 苏娟 吴树人 吴建新 秦燕 |
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作者单位: | 1. 云南大理学院基础医学院生理学与病理生理学教研室,大理,671000 2. 成都,四川大学华西基础医学与法医学院病理生理学教研室 |
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基金项目: | 教育部高等学校博士学科点专项科研基金 |
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摘 要: | 目的探讨同型半胱氨酸(Hcy)对人脐静脉血管平滑肌细胞(VSMCs)氧化损伤的作用及机制。方法用含不同剂量Hcy(50~1000μmol/L)的培养基培养VSMCs24h后,以分光光度比色法分别测定细胞内丙二醛(MDA)含量和超氧化物酶(SOD)、过氧化氢酶(CAT)活力的改变。结果随Hcy浓度增加,VSMCs内MDA的含量明显增加,SOD和CAT的活力也显著升高。Hcy明显促进了VSMCs的氧化。结论Hcy可直接诱导VSMCs的氧化损伤。
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关 键 词: | 同型半胱氨酸 平滑肌细胞 氧化损伤 |
Study on the oxidative injury of smooth muscle cells induced by homocysteine |
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Affiliation: | SU Juan, WANG Shu-ren,WU Jian-xin, et al. (Department of Physiology and Pathophysiology, School of Basic Medicine, Liaoning University, Dali 671000, China) |
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Abstract: | Objective The mechanism of homocysteine(Hcy) induced oxidative injury on human vascular smooth muscle cells(VSMCs) was studied. Methods VSMCs were incubated with different levels of Hey (50 -1000μmol/L) for 24 hours. The contents of MDA,the activities of SOD and CAT were measured by chromatometry. Results Hey significantly increased the level of MDA ,SOD and CAT in a dose-dependent manner. Conclusion Hcy may induce oxidative injury on VSMCs. |
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Keywords: | Homocysteine Smooth muscle cell Oxidative injury |
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