| 奥瑞凝胶抗反流性食管炎模型大鼠食管黏膜损伤的实验研究 |
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| 引用本文： | 王小晓,魏明,段飞,刘娟.奥瑞凝胶抗反流性食管炎模型大鼠食管黏膜损伤的实验研究[J].中药新药与临床药理,2010,21(1). |
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| 作者姓名： | 王小晓 魏明 段飞 刘娟 |
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| 作者单位： | 河南中医学院第一附属医院,郑州,450000 |
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| 基金项目： | 河南省科技厅重点科技攻关项目 |
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| 摘 要： | 目的观察奥瑞凝胶对反流性食管炎模型大鼠食管黏膜的保护和修复作用。方法采用半幽门结扎加贲门肌切开术复制反流性食管炎大鼠模型,设模型组、奥瑞凝胶3个剂量组、阳性药对照组、凝胶赋形剂组和假手术对照组;术后7d开始给药,给药14d后观察各组大鼠一般状态、食管黏膜的肉眼观察表现、病理组织学改变。结果奥瑞凝胶组大鼠食管黏膜肉眼观察和病理组织学观察,与模型组比较差异均有统计学意义;奥瑞凝胶组大鼠食管黏膜炎症程度减轻,病理学表现趋于正常。结论奥瑞凝胶能减轻反流性食管炎大鼠食管黏膜病变程度,提示其有保护和修复食管黏膜损伤的作用。
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| 关 键 词： | 奥瑞凝胶 反流性食管炎 动物模型 黏膜损伤 |
Study on Aorui Gel in Preventing Esophageal Mucosa from Injury in Reflux Esophagitis Rats |
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| WANG Xiaoxiao,WEI Ming,DUAN Fei,LIU Juan.Study on Aorui Gel in Preventing Esophageal Mucosa from Injury in Reflux Esophagitis Rats[J].Traditional Chinese Drug Research & Clinical Pharmacology,2010,21(1). |
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| Authors: | WANG Xiaoxiao WEI Ming DUAN Fei LIU Juan |
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| Institution: | WANG Xiaoxiao,WEI Ming,DUAN Fei,LIU Juan(The First Affiliated Hospital of Henan College of TCM,Zhengzhou 450000,China) |
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| Abstract: | Objective To observe protective and repairing effect of Aorui Gel on esophageal mucosa injury in reflux esophagitis rats. Methods Rat models of reflux esophagitis were established by partial pylori ligation plus cardiomyotomy. Model control group,low-,middle-and high-dose Aorui Gel groups,positive control group,excipient control group and sham operation group were set up. Rats were treated with the corresponding drugs 7 days after operation. After treatment for 14 days,the rats'general state,and macroscopi... |
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| Keywords: | Aorui Gel Reflux Esophagitis Animal Models Mucosal injury |
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