| 普伐他汀对糖尿病伴高脂血症患者血脂、血小板活化功能及血液流变学的影响 |
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| 引用本文： | 吴志坚,林扬闯.普伐他汀对糖尿病伴高脂血症患者血脂、血小板活化功能及血液流变学的影响[J].江西医药,2008,43(10). |
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| 作者姓名： | 吴志坚 林扬闯 |
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| 作者单位： | 1. 浙江省台州医院路桥院区心内科
2. 浙江省台州市立医院心内科,台州,318000 |
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| 摘 要： | 目的探讨普伐他汀对2型糖尿病伴高脂血症患者血脂、血小板膜糖蛋白和血液流变学的影响。方法选择80例2型糖尿病伴高脂血症患者,予以普伐他汀片10mgqd口服,12周为1个疗程。测定治疗前和治疗4、12周后患者血脂、血小板活化指标CD62p和CD63及血液流变学指标的变化。结果治疗4、12周后患者血脂TC、TG、LDL-C和血小板膜糖蛋白CD62p、CD63水平均较治疗前明显降低(P<0.05或P<0.01),且血液流变学指标均有不同程度的改善。结论普伐他汀对2型糖尿病伴高脂血症患者具有降脂和抑制血小板活化作用,能明显改善血液流变学指标,临床应用疗效确切,不良反应少。
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| 关 键 词： | 2型糖尿病 高脂血症 普伐他汀 血脂 血小板活化 血液流变学 |
The effects of Pravastatin on blood lipids,platelet activity and hemorheology in diabetic patients with hyperlipidaemia |
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| Wu Zhijian,Lin Yangchuang.The effects of Pravastatin on blood lipids,platelet activity and hemorheology in diabetic patients with hyperlipidaemia[J].Jiangxi Medical Journal,2008,43(10). |
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| Authors: | Wu Zhijian Lin Yangchuang |
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| Institution: | Wu Zhijian1,Lin Yangchuang2 |
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| Abstract: | Objective To study the effects of pravastatin on blood lipids,platelet activity and hemorheology in type 2 diabetic patients with hyperlipidaemia.Methods Eighty patients with type 2 diabete complicated hyperlipidaemia had been treated with 10mg pravas-tatin per day for 12 weeks.The levels of blood lipids,platelet activity and hemorheology were measured before and after 4 and 12 weeks treatment.Results The levels of TC,TG,LDL-C,CD62p and CD63 significantly decreased and hemorheology were improved ob-viously when treated with pravastatin for 4 and 12 weeks.Conclusion Pravastatin can not only significantly reduce blood lipids and platelet activity but also obviously improve hemorheology in diabetic patients with hyperlipidaemia. |
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| Keywords: | type 2 diabetic hyperlipidaemia Pravastatin blood lipids platelet activity hemorheology |
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