肠缺血再灌注损伤防治研究的进展

肠缺血-再灌注损伤（ischemia- reperfusion injury，简称I／R）是外科实践中的重要问题，在小肠移植、严重感染、创伤、休克、心肺功能不全等疾患的病理演变过程中起重要作用。肠I／R的后果，不仅可以引起肠粘膜的局部组织损害，而且可以导致肠道菌群移位和肠吸收功能的改变，以及远处器官的损害，甚至发生多系统器官功能不全综合症。本文阐述了近年来在其发生机理及防治措施方面的研究进展，为今后临床工作提供指导。

Ischemia-Reperfusion Injury of the Intestine and Protective Strategies Against Injury

The ischemia-reperfusion injury, which is called I/R, is an important problem in the surgical practices. It plays an important role in the developing of pathology, such as the small intestine transplantation, the serious infection, the wound, the shock, the cardiorespiratory functional defeat. The consequence of intestinal I/R, not only causes partial histologic lesion of intestinal mucosa, more over may cause intestinal bacteria colony shifting, changes the intestines absorption function, as well as damages to the distance organ, even leads to the multi-systems organ function defect syndrome. This article explained its mechanism and prevention measure for the past few years and hoped to provide the basis for the future clinical work.