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目的通过最新一轮的北京地区儿童青少年血脂调查,建立新的正常参考值。方法于2004-09,随机选取7~18岁北京市中小学生共971人,均来自北京市区及郊区各县。根据年龄(每3岁为一年龄段)及性别分为8组(7~9岁男、女组;~12岁男、女组;~15岁男、女组;~18岁男、女组),应用日立7060型全自动生化分析仪检测其空腹血浆总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)浓度,分别取TC、LDL-C第75百分位及第90百分位点作为临界高限及高胆固醇血症浓度,取TG第90百分位点作为高甘油三酯血症浓度,取HDL-C第5百分位点作为低高密度脂蛋白浓度,建立北京地区儿童血脂参考值。结果971名儿童的血浆脂蛋白含量值呈正偏态分布,7~9岁男女性别组间血脂4项浓度;~12岁性别组间TG含量女高于男,余3项无统计学差异;~15岁性别组间TC及LDL-C含量女高于男,余2项无统计学差异;~18岁性别组间TC及HDL-C女高于男,余2项无统计学差异。结论通过对971名北京市中小学生的血脂调查,建立了北京地区不同年龄性别儿童青少年的血脂正常值,确立了临界高胆固醇和高胆固醇血症浓度、高甘油三酯血症浓度和低高密度脂蛋白浓度。

Investigation of plasma lipid value in 7 ～ 18 years old adolescents in Beijing area

Objective This study aimed to establish the latest normal value of plasma lipid in 7~18 years old children in Beijing via the investigation.Methods A total of 971 healthy school students were chosen randomly,all coming from Beijing city and its counties.They were divided into eight groups according to their gender and age (7~9 years old boys and girls; ~12 years old boys and girls; ~15 years old boys and girls; ~18 years old boys and girls).Total cholesterol (TC),triglyceride (TG),high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C) were detected by HITACHI 7060 automatic biochemical analyzer.The 75th and 90th percentiles of TC and LDL-C levels were adopted as the borderline and high of hypercholesterolemia.The 90th percentile of TG was served as the cut-off of hypertriglyceridemia.And the 5th of HDL-C acted as the lower limit to establish the new criteria of dyslipidemia in Beijing children.Results Serum lipid values in 971 school students took on a positive skew distribution.There was no statistical significance between males and females in 7 to 9 years old group of their TC,TG,HDL-C and LDL-C levels.In ~12 years old group,there was a difference between the two sexes in TG level.While in ~15 years old group,TC and LDL-C levels in females were both higher than those of males.In ~18 years old group,TC and HDL-C values were higher in females than in males.Conclusion New criteria of plasma lipid values in children in Beijing are established by our investigation in 971 healthy school students.Age and sex have been analyzed.Borderline and high of TC and LDL-C levels have been settled.Cut-off of hypertriglyceridemia and hypo-high density lipoprotein cholesterolemia have also been established.