支气管成形肺叶切除术治疗218例非小细胞肺癌

目的 探讨支气管成形肺叶切除术治疗非小细胞肺癌(NSCLC)的手术适应证、并发症以及影响预后的相关因素.方法 回顾性分析218例接受支气管成形肺叶切除术的NSCLC病人的临床资料.结果 手术死亡率为3.2%,并发症发生率为20.2%,1、3、5年生存率分别为76%、55%、42%.N分期(P=0.000)和术后辅助化疗(P=0.021)是影响生存率的独立因素.结论 对于肺功能正常病人而言,支气管成形肺叶切除术同样是治疗NSCLC的有效手段.但对于N1和N<,2>,特别是N<,2>病人应慎重手术,可考虑先行新辅助化疗,术后进行辅助化疗以提高疗效.

Bronchoplastic lobectomy in non-small cell lung cancer: review of 218 patients

Objective To investigate the indications, postoperative complications and predicting factors after sleeve lobectomy for NSCLC. Methods 218 patients with NSCLC underwent sleeve lobectomy. Results The mortality was 3.2% and morbidity 20.2%. The overall survival rate at 1, 3 and 5 years was 76%, 55% and 42, respectively. Multivariate analysis indicated that N stage (P=0.000) and postoperative adjuvant chemotherapy (P=0.021) were significant factors affecting survival. Conclusion For patients with NSCLC, bronchoplastic lobectomy are an adequate cancer operation. Preoperative and postoperative adjuvant chemo- therapy would play an important role in prolenging survival, particularly in patients with positive N1 or N2 lymph nodes.