| 补肾、健脾、活血中药及活髓片、活髓膏对溶血性贫血大鼠造血及GM-CSF、EPO、IL-2的影响 |
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| 引用本文： | 曹克俭.补肾、健脾、活血中药及活髓片、活髓膏对溶血性贫血大鼠造血及GM-CSF、EPO、IL-2的影响[J].中国中西医结合杂志,2005(Z1). |
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| 作者姓名： | 曹克俭 |
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| 作者单位： | 香港大学中医药学院 |
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| 基金项目： | 国家中医药管理局重点科研基金资助(No．972114) |
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| 摘 要： | 目的观察补肾、健脾、活血中药对溶血性贫血大鼠造血及红细胞生成素(GM-CSF)、粒-巨噬细胞集落刺激因子(EPO)、白介素-2(IL-2)的影响。方法采用乙酰苯肼造成大鼠溶血性贫血,对造模成功者分别给予补肾药、健脾药、活血药、活髓片、活髓片与活髓膏合用,共13天。用放射免疫法检测血中GM- CSF、EPO及IL-2。结果健脾组大鼠存活率及血红蛋白均最高；对GM-CSF的影响,补肾组、健脾组及合治组高于正常组、对照组、活血组(P＜0．05)；造模大鼠各组IL-2均高于正常组,实验各组之间差异无显著性(P＞0．05)；健脾组EPO最高,高于补肾组、活血组及活髓组(P＜0．05),各用药组与对照组比较差异有显著性(P＜0．05,P＜0．01)。结论补肾、健脾、活血中药促进造血的机制与环节有所不同。
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| 关 键 词： | 补肾、健脾、活血中药 溶血性贫血 血红蛋白 红细胞生成素 粒-巨噬细胞集落刺激因子 白介素-2 |
Effect of Chinese Herbs for Touifying Shen,Invigorating Pi and Promoting Blood Circulation and Huosui Tablet,Huosul Onintment on Hematopoiesis,GM-SCF,EPO and IL-2 in Rats with Hemolytic Anemia |
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| Authors: | CAO Ke-jian College of Traditional Chinese Medicine Hongkong University |
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| Institution: | CAO Ke-jian College of Traditional Chinese Medicine; Hongkong University; |
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| Abstract: | Objective To investigate the effect of Chinese herbs for tonifying Shen,invigorating Pi and pro- moting blood circulation on hematopoesis,granulocyte-macrophage colony stimulating factor(GM-CSF),erythro- poietin(EPO)and interleukin-2(IL-2)in rats with hemolytic anemia(HA).Methods The HA rats model were established by using acetyl phenyl hydrazine(APH),and the successful model rats were treated with Chinese herbs for tonifying Shen,invigorating Pi,promoting blood circulation,Huoxue tablet,Huoxue tablet combi... |
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| Keywords: | Chinese herbs for tonifying Shen invigorating Pi and promoting blood circulation hemolytic anemia hemoglobin granulocyte-macrophage colony stimulating factor erythropoietin interleukin-2 |
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