乙肝患者血清HBsAg与HBsAb双阳性的特殊模式

目的通过分析乙肝患者乙型肝炎病毒(HBV)血清标志物乙型肝炎表面抗原(HBsAg)与乙型肝炎表面抗体(HBsAb)同时阳性罕见模式的病例,探讨其存在原因及临床价值。方法应用ELISA法对乙肝感染者HBV标志物进行初筛,再采用微粒子酶免疫化学发光分析法(MEIA)检测其浓度;对HBsAg与HBsAb同时阳性者应用PCR方法定量检测HBV-DNA,并结合患者的临床特点进行综合分析。结果 HBsAg与HBsAb同时阳性的检出率为4.46%,检出率最高为重型肝炎(18.18%),其次为慢性肝炎(9.09%)和肝硬化(8.96%)。重型肝炎、慢性肝炎和肝硬化HBsAg与HBsAb同时阳性率明显高于无症状携带者和急性肝炎(P0.01)。HBsAg高滴度组HBV-DNA病毒载量及阳性率明显高于低滴度组(P0.01)。HBs-Ab值与HBV-DNA病毒载量间无明显相关性(P0.05)。结论 HBsAg与HBsAb同时阳性的模式,是由多种原因引起,HBV亚型双重感染可能是主要原因。

Analysis on Special Mode of Patients with Positive HBsAg and Anti-HBs Simultaneously

Objective To analyze the rare HBV marker model with HBsAg and HBsAb simultaneously positive in the sera of patients with hepatitis B virus infection,and to explore the existence cause and the clinical value of the rare model. Methods The HBsAg,anti-HBs,HBeAg,anti-HBe,and anti-HBc in the sera of patients with hepatitis B virus infection were detected by ELISA and MEIA.HBV-DNA in the patients with HBsAg and HBsAb simultaneously positive was determined by PCR,and their clinical characteristics were comprehensi...