Pharmacokinetics of intravenously administered bumetanide in man |
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Authors: | Pertti J. Pentikäinen Pertti J. Neuvonen Matti Kekki Aneri Penttilä |
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Affiliation: | (1) Second Department of Medicine, University of Helsinki, Haartmaninkatu 4, SF-00290 Helsinki 29, Finland;(2) Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland;(3) Research Laboratories of Medica Ltd, Helsinki, Finland |
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Abstract: | Disposition of [14C] bumetanide administered intravenously to four healthy volunteers could be described by a triexponential equation. The mean half-lives associated with each exponent were 5.9 min, 46 min, and 3.1 hr, respectively. The largest fraction of dose was eliminated during the second phase; only 17% was eliminated during the last phase. The total plasma clearance averaged 228 ml/min, with renal clearance about one-half of this value. The recovery of unchanged bumetanide in urine over 2 days was 47% of the dose, while the total recovery of radioactivity in urine averaged 82% of dose. In plasma 93% of bumetanide was bound to proteins. Thus bumetanide is rapidly eliminated by both renal and nonrenal mechanisms. The elimination kinetics resembled those described for furosemide. |
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Keywords: | bumetanide diuretics pharmacokinetics three-compartment model protein binding |
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