微囊化嗜铬细胞对癌症病人止痛作用研究

目的寻找行之有效的止痛方法,观察微囊化嗜铬细胞(BCC)对晚期癌症病人的止痛作用.方法用新鲜牛肾上腺分离嗜铬细胞,微囊化处理,经腰穿植入癌症病人脊髓蛛网膜下腔,观察其镇痛效果及不良反应.结果BCC移植后92.30%的病人疼痛完全缓解,不再需任何止痛药;2例疼痛明显减轻,经1周后2次移植完全疼痛缓解;1例疼痛虽有减轻,但仍需服半量止痛药.结论本法止痛作用持续时间长,适用于癌症病人的应用.

A clinical observe on analgesia induced by microencapulated bovine chromaffin cell implantation to the spinal subarachnoid spce in

Objective The pain is important problem in treatment of the cancer patients.To evaluate the analgest efficacy and toxicity of the xenogeneic bovine chiomaffin cell(BCC) in the treatment of cancer patients.BCC was implanted into the spinal subarachoind space of 39 patients suffering from terminal cancer pain.Method Bovine adrenal glands were removed,Chromaffin cells were separated using enzymatic digestion technique.Microencapulated bovine chromaffin cell was implanted into the spinal subarachoind space of 39 cancer patients.Result Pain in 36 patients was ameliorated,and no further analgesic drug was necessary,or the dosage of analgesic drug was reduced.the analgesia was maintained over 290 days.No obvious side effects were observed.Conclusion BCC xenograft in the spinal subarachnoid space could rapidly produce obvious antinociceptive effects and is saft analgesia method in cancer patients.