2型糖尿病患者血清脂联素和胰岛素敏感性的相关性

目的探讨正常人和2型糖尿病（T2DM）患者血清脂联素（APN）和胰岛素敏感性的相关性。方法正常对照组20例，T2DM58例按体重指数（BMI）又分为正常体重组（16例）、超重组（22例）和肥胖组（20例）。测定正常对照组和T2DM各组患者的胰岛素抵抗指数（HOMA-IR）、APN、糖化血红蛋白（HbA1C）、空腹血糖（FPG）和空腹胰岛素（FINS）水平。结果与正常对照组相比，T2DM超重组和肥胖组的APN显著降低（均P〈0．01），肥胖组APN较超重组显著降低，超重组APN较正常体重组显著降低（均P〈0．05）；与正常对照组相比，T2DM各组HOMA-IR显著升高（均P〈0．01）。所有研究个体APN与BMI（r=-0．538，P〈0．01）和HOMA-IR（r=-0．459，P〈0．01）呈显著负相关。结论T2DM患者血清APN水平显著降低，并以超重组和肥胖组患者降低更为明显；APN与HOMA-IR和BMI呈显著负相关。

Correlation between serum adiponectin level and insulin sensitivity in patients with type 2 diabetes mellitus

Objective To assay the serum adiponectin(APN) levels in normal subjects and the patients with type 2 diabetes mellitus(T2DM),and to discuss the correlation between APN and insulin sensitivity.Methods Twenty normal controls and 58 T2DM subjects were included in this study.The latter were divided into normal weightgroup,overweight group and obesity group according to their body mass index(BMI).HOMA-IRwas assessed in all groups.Meanwhile,the parameters such as fasting APN,HbA_(1C),fasting plasma glucose and insulin levels were also measured.Results Compared with normal control group,the APN levels in overweight and obesity groups were significantly decreased(P<0.01).The APN levels in obesity group were significantly lower than those in(overweight) group,and the APN levels in overweight group were significantly lower than those in normal weight group(P<0.05).Compared with normal control group,HOMA-IRin T2DM groups was significantly increased(P<0.01).Serum APN levels were negatively correlated with BMI(r=(-0.538,)P<0.01)and HOMA-IR(r=-0.459,P<0.01) in all subjects.Conclusion In patients with T2DM,serum APN level issignificantly decreased,especially in the overweight and obesity people.APN is negatively correlated with BMI and HOMA-IR.