Laboratory parameters in the natural history of liver cirrhosis |
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Authors: | Alessandro Milani Laura Marra Massimo Siciliano Lodovico Rossi |
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Institution: | (1) Istituto di Patologia Speciale Medica, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Roma, Italia |
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Abstract: | Summary The aim of the present study was to evaluate the changes of common laboratory parameters in the natural evolution of liver
cirrhosis, as well as their relationships with the occurrence of ascites onset and death. Routine laboratory findings of 458
patients suffering from liver cirrhosis admitted to a 9-year follow-up period were retrospectively investigated, but only
data of the 138 subjects (95 males and 43 females) who died within the follow-up period were considered. Data were grouped
into different classes according to the months elapsed before ascites onset or death. The statistical differences among the
various groups were evaluated employing analysis of variance and Tukey’s test. No laboratory parameter showed statistically
significant changes before or at the time of ascites onset, while significant modifications occurred in four liver indexes
(albumin, total bilirubin, platelet count and gammaglobulin percentage) during the course of the illness, thus confirming
the reliable prognostic value of these laboratory parameters in liver cirrhosis. |
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Keywords: | Follow-up study Laboratory parameters Liver cirrhosis Natural history Prognosis |
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