| mGluR 1/5介导的下游信号通路 |
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| 引用本文： | 曹芳丽,涂海军,刘剑峰. mGluR 1/5介导的下游信号通路[J]. 医学分子生物学杂志, 2007, 4(2): 136-139 |
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| 作者姓名： | 曹芳丽 涂海军 刘剑峰 |
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| 作者单位： | 华中科技大学生命科学与技术学院生物物理与生物化学研究所,武汉市,430074;华中科技大学生命科学与技术学院生物物理与生物化学研究所,武汉市,430074;华中科技大学生命科学与技术学院生物物理与生物化学研究所,武汉市,430074 |
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| 摘 要： | 代谢型谷氨酸受体1/5(mGluR1/5)是G蛋白偶联受体家族C的重要成员之一,该受体及其介导的下游信号在调节神经系统的正常生理功能起着非常重要作用,并与相关神经系统退行性疾病密切相关。文章介绍了mGluR1/5所介导的信号通路、信号通路调控的分子机制以及其他GPCR受体的相互作用对信号共同调节的分子机制等方面最新研究进展。
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| 关 键 词： | G蛋白偶联受体 代谢型谷氨酸受体 信号转导 |
| 修稿时间： | 2006-11-28 |
Signal Transduction Induced by mGluR 1/5 |
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| CAO Fangli,TU Haijun,LIU Jianfeng. Signal Transduction Induced by mGluR 1/5[J]. Journal of Medical Molecular Biology, 2007, 4(2): 136-139 |
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| Authors: | CAO Fangli TU Haijun LIU Jianfeng |
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| Abstract: | Metabotropic glutamate receptors 1/5 (mGluR 1/5) is an important member of family of C G protein coupled receptor (GPCRs). The signal transduction induced by mGluR 1/5 plays an important role in the regulation of the central nervous system functions, and is involved in many neurodegenerative diseases. This review focuses on the recent advances in the study of the signaling, regulatory properties of mGluR 1/5, and the regulation of signaling by the interactions between mGluR 1/5 and other GPCRs |
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| Keywords: | G protein coupled receptor metabotropic glutamate receptors signal transduction |
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