Cerebral Segmental Polyarteritis of Unknown Aetiology in Sheep |
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| Authors: | A. Schock S.F.E. Scholes F.E. Howie D. Buxton |
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| Affiliation: | ∗VLA Lasswade, Pentland Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ;†SAC Edinburgh Disease Surveillance Centre, SAC Veterinary Services, Allan Watt Building, Bush Estate, Penicuik, Midlothian EH26 0QE;‡Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian EH26 0PZ, UK |
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| Abstract: | Vasculitis affecting the meningeal elastic arteries was identified in six sheep of various breeds during routine diagnostic investigation. The lesions consisted of multifocal intimal proliferation, thickening of the tunica media, multifocal infiltration of the media by inflammatory cells and more extensive perivascular accumulation of lymphocytes and plasma cells within the tunica adventitia. Fibrinoid necrosis affected an intergyral artery in one sheep. Immunohistochemistry failed to demonstrate pestivirus antigen associated with the lesions and no alternative aetiology was defined. Possible causes of meningeal segmental polyarteritis in sheep are discussed. |
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| Keywords: | cerebrum polyarteritis sheep vasculitis |
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