Comparison of Intranasal and Intramuscular Immunization against Human Immunodeficiency Virus Type 1 with a DNA-Monophosphoryl Lipid A Adjuvant Vaccine |
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| Authors: | Shin Sasaki Kenji Hamajima Jun Fukushima Atsushi Ihata Norihisa Ishii Itsuo Gorai Fumiki Hirahara Hiroshi Mohri Kenji Okuda |
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| Affiliation: | Departments of Bacteriology,1. First Internal Medicine,2. Dermatology,3. and Obstetrics and Gynecology,4. Yokohama City University School of Medicine, Yokohama 236, Japan |
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| Abstract: | We compared immune responses to intranasal and intramuscular DNA vaccinations against human immunodeficiency virus type 1 with monophosphoryl lipid A (MPL) used as an adjuvant. Both routes of vaccination resulted in similar levels of cell-mediated immunity, but the intestinal secretory immunoglobulin A response was higher following intranasal immunization than after intramuscular immunization. MPL demonstrated its adjuvanticity in vaccination by both routes. |
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