| 甘露糖结合凝集素与艾滋病相关性的研究 |
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| 引用本文： | 姜枫,彭勃,尚佳,张庶民.甘露糖结合凝集素与艾滋病相关性的研究[J].河南中医学院学报,2006,21(2):1-4. |
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| 作者姓名： | 姜枫 彭勃 尚佳 张庶民 |
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| 作者单位： | [1]上海中医药大学,上海浦东201203 [2]河南中医学院艾滋病研究所,河南郑州450008 [3]河南省人民医院,河南郑州450003 [4]中国药品生物制品鉴定所,北京100050 |
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| 基金项目： | 中国科学院资助项目
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科技部专项基金 |
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| 摘 要： | 甘露糖结合凝集素(mannose binding lectin or mannan binding lectin;MBL)是一种存在于血清中的C型凝集素.MBL通过结合病原生物表面的甘露糖等糖基受体而直接介导调理吞噬作用和/或通过MBL途径激活补体,在机体的固有性免疫防御中发挥重要作用.HIV-1的表面包膜蛋白gp120/gp41为机体固有免疫系统通过MBL的攻击提供了潜在位点.MBL主要通过四个环节在艾滋病中发挥作用:补体活化、中和作用、调理作用和封闭DC细胞特异的ICAM3结合的非整合素.对于MBL在艾滋病的疾病进展和疾病传播中的作用认识不一,有待进一步研究.
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| 关 键 词： | 甘露糖结合凝集素 补体活化 中和作用 调理作用 DC-SIGN 艾滋病 |
| 文章编号： | 1672-6839(2006)02-0001-04 |
| 修稿时间： | 2005年12月25 |
A Study on Relativity of Mannose Binding Lectin or Mannan Binding Lectin (MBL) and Acquired Immunodeficiency Syndrome (AIDS) |
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| Jiang Feng,Peng Bo,Shang Jia,Zhang Shumin.A Study on Relativity of Mannose Binding Lectin or Mannan Binding Lectin (MBL) and Acquired Immunodeficiency Syndrome (AIDS)[J].Journal of Henan University of Chinese Medicine,2006,21(2):1-4. |
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| Authors: | Jiang Feng Peng Bo Shang Jia Zhang Shumin |
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| Abstract: | Mannose binding lectin(MBL),or mannan binding lectin,is a member of C type collectin proteins in the plasma.It plays an important role in the innate immune system by binding to the saccharide receptor of mannose/mannan on the surfaces of pathogens.The envelope protein (gp120/gp41) of HIV-1 provides a potential site of attack by the innate immune system through MBL. The mechanism that MBL affect HIV disease are primary based on complement activation,opsonization,neutralization of HIV by MBL and blocking dendritic cell specific intracellular adhension molecule 3 grabbing nonintegrin(DC-SIGN). The effects of MBL on HIV disease progression and transmission are equivocal with some studies showing positive effects and other showing no effect or negative effects. |
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| Keywords: | MBL Complement Neutralization Opsonization DC-SIGN AIDS |
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