| 结肠,直肠癌APC和MCC基因的分子病理学研究 |
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| 引用本文： | 李向阳,王建清.结肠,直肠癌APC和MCC基因的分子病理学研究[J].解放军医学杂志,1995,20(4):260-261. |
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| 作者姓名： | 李向阳 王建清 |
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| 作者单位： | 解放军第２０９医院 |
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| 摘 要： | 用ＰＣ技术对２２例结肠、直肠癌标本检测ＡＰＣ和ＭＣＣ基因杂合子的丢失。结果显示：ＡＰＣ基因第１１外显子有９例为纯合子，１３例为杂合子，后者有３例杂合子丢失，占２３．１％；ＭＣＣ基因第１０外显子有８例为纯合子，１４例为杂合子，后者有４例杂合子丢失、占２８．６％。
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| 关 键 词： | 癌基因 聚合酶链反应 结肠肿瘤 直肠肿瘤 病理学 |
A MOLECULAR PATHOLOGICAL STUDY OF APC AND MCC GENES IN COLORECTAL CANCER |
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| Li Xiangyang, Zhang Fuguo,Liu Yingshan.A MOLECULAR PATHOLOGICAL STUDY OF APC AND MCC GENES IN COLORECTAL CANCER[J].Medical Journal of Chinese People's Liberation Army,1995,20(4):260-261. |
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| Authors: | Li Xiangyang Zhang Fuguo Liu Yingshan |
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| Institution: | Li Xiangyang, Zhang Fuguo,Liu Yingshan. Department of pathology,209th hospital of PLA. Mu Danjiang 157011 |
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| Abstract: | PCR technique was used to examine 22 cases colorectal cancer for loss of heterozygosity(LOH) of APC or Mcc genes, It was shown that at the APC exon 11 locus, 13 of 22 patients were heterozygous,3(23.1%)of these l3 cases demonstrated LOH and 14 patients represented heterozygosity involving the MCC exon 10 locus,4 out of these 14 cases(28. 6%)shwned LOH. |
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| Keywords: | colorectal cancer oncogene PCR loss of heterozygosity |
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