Spontaneous inhibitory postsynaptic potentials in guinea pig neocortex and olfactory cortex neurones |
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| Authors: | M Galvan P Franz A Constanti |
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| Affiliation: | 1. Department of Physiology, University of Munich, Pettenkoferstrasse 12, D-8000 München 2 F.R.G.;2. MRC Neuropharmacology Research Group, Department of Pharmacology, The School of Pharmacy, 29/39 Brunswick Square, London, WC1N 1AX U.K. |
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| Abstract: | The membrane potential of olfactory cortex and neocortex neurones in vitro was recorded using conventional microelectrode techniques. During recordings with KCl- or CsCl-filled microelectrodes, spontaneous, subthreshold, transient membrane depolarizations were observed. These were abolished by the GABAA-receptor antagonist, bicuculline methiodide, and were prolonged by the barbiturate pentobarbitone. In most cells they were abolished by tetrodotoxin. It is concluded that these spontaneous depolarizations are inhibitory postsynaptic potentials arising from spontaneous activity in inhibitory interneurones. |
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| Keywords: | neocortex slices olfactory cortex slices inhibitory postsynaptic potential γ-aminobutyric acid guinea pig |
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