Efficacy of auxiliary therapy with Danggui Buxue Decoction No.1 (当归补血汤1号) in treating patients of non-small cell lung cancer at peri-operational stage |
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引用本文: | 杜庆聪,杨奎忠,孙雪飞.Efficacy of auxiliary therapy with Danggui Buxue Decoction No.1 (当归补血汤1号) in treating patients of non-small cell lung cancer at peri-operational stage[J].Chinese Journal of Integrated Traditional and Western Medicine,2009,15(3):184-188. |
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作者姓名: | 杜庆聪 杨奎忠 孙雪飞 |
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作者单位: | The Fourteen Area Wujing Shandong Zongdui Hospital |
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摘 要: | Objective:To observe the therapeutic efficacy of Danggui Buxue Decoction No.1(当归补血汤1号,DB1) in treating patients of non-small cell lung cancer(NSCLC) at the peri-operational stage and its impact on the patients' immune function.Methods:Eighty-two NSCLC patients were randomly assigned to two groups equally,the control group and the test group,they were given conventional treatment,while to the test group, DB1 were given additionally.The observation was conducted by testing the changes of T-lymphocyte subse...
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关 键 词: | non-small cell lung cancer peri-operational stage immune function Danggui Buxue Decoction No.1 immunotherapy |
Efficacy of auxiliary therapy with Danggui Buxue Decoction No.1 (当归补血汤1号) in treating patients of non-small cell lung cancer at peri-operational stage |
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Authors: | Qing-cong Du Kui-zhong Yang and Xue-fei Sun |
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Institution: | (1) The Fourteen Area, Wujing Shandong Zongdui Hospital, Jinan, 250014, China |
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Abstract: | Objective To observe the therapeutic efficacy of Danggui Buxue Decoction No.1 (当归补血汤1号, DB1) in treating patients of non-small cell
lung cancer (NSCLC) at the peri-operational stage and its impact on the patients’ immune function.
Methods Eighty-two NSCLC patients were randomly assigned to two groups equally, the control group and the test group, they were given
conventional treatment, while to the test group, DB1 were given additionally. The observation was conducted by testing the
changes of T-lymphocyte subsets, natural killer (NK) cell activity, serum levels of immunoglobulin (IgA, IgM, IgG), interleukin-2
(IL-2), tumor necrosis factor α (TNF-α), cytokeratin fragment 19 (CYFRA21-1) and carcinoembryonic antigen (CEA) in NSCLC patients
before and after administration of DB1, and analyzing the patients’ general condition.
Results The level of CD3+, CD4+, the ratio of CD4 and CD8+, IgA, IgM, IgG and IL-2 decreased in patients with NSCLC on day 1 after operation, and the level of CD8 and TNF-α increased
compared to pre-operation. While the levels of CD3+, CD4+, CD4 /CD8+, NK cell activity, serum IgA, IgM, IgG, IL-2 began to elevate, CD8 and TNF-α levels began to decline in patients administered
with DB1 on day 3 after the operation, earlier than patients who did not use the decoction. The level of CYFRA21-1 and CEA,
was immediately decreased after operation in both groups.
Conclusions Applying DB1 to NSCLC patients at an early post-operational stage could alleviate the impairment and accelerate the recovery
of immune function of patients to enhance their immunity. DB1 also shows an anti-tumor action to a certain degree. |
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Keywords: | non-small cell lung cancer peri-operational stage immune function Danggui Buxue Decoction No 1 immunotherapy |
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