EEG-related functional MRI in benign childhood epilepsy with centrotemporal spikes |
| |
Authors: | Boor Stephan Vucurevic Goran Pfleiderer Christian Stoeter Peter Kutschke Georg Boor Rainer |
| |
Affiliation: | Institute for Neuroradiology, University Children's Hospital, Johannes-Gutenberg University, D-55101 Mainz, Germany. boor@neuroradio.klinik.uni-mainz.de |
| |
Abstract: | The localization of epileptic foci is an important issue in children with extratemporal epilepsies. However, the value of noninvasive methods such as the EEG-assisted functional magnetic resonance imaging (fMRI) has not been sufficiently investigated in children. As a model of extratemporal epilepsies, we studied 7 patients aged 5 to 12 (median 10) years with benign childhood epilepsy and centrotemporal (rolandic) spikes. Interictal spikes were recorded during the fMRI acquisition on a MR-compatible battery-powered digital EEG system with 16 channels. The fMRI sequences were correlated off-line with the EEG spikes and analyzed with the software Statistical Parametrical Mapping SPM99. The fMRI results demonstrated the spike-related activation in the perisylvian central region in three patients; we could not demonstrate fMRI activation despite active spiking in 2 patients, and 2 patients did not produce sufficient spikes for fMRI analysis. We currently consider the spike-related fMRI as a research tool that localizes epileptic activity in selected patients. Further improvements of the technique are necessary to allow a clinical application of this method. |
| |
Keywords: | fMRI Functional imaging BOLD Epilepsy BECTS |
本文献已被 PubMed 等数据库收录! |
|