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| Expression of E-Cadherin in Oral Squamous Cell Carcinoma is Associated with Clinical Prognosis | |
| 引用本文： | Jianming Zhang Wei Zhang Ping Gao Yanqiu Li Changyi Li Sakan Maeda. Expression of E-Cadherin in Oral Squamous Cell Carcinoma is Associated with Clinical Prognosis[J]. 中国肿瘤临床(英文版), 2006, 3(3): 181-184. DOI: 10.1007/s11805-006-0115-z |
| 作者姓名： | Jianming Zhang Wei Zhang Ping Gao Yanqiu Li Changyi Li Sakan Maeda |
| 作者单位： | Division of |
| 摘 要： | E-cadherin is a member of the cadherin superfamily, which are calcium-dependent intercellular adhesion molecules believed to play a role in cell recognition and segregation, morphogenetic regula- tion, and tumor suppression,[1] Reduced expression of E-cad… |
| 关 键 词： | 口腔鳞状细胞癌 疾病预防 病理机制 治疗 |
| 收稿时间： | 2006-05-09 |
| 修稿时间： | 2006-06-07 |
Expression of E-cadherin in oral squamous cell carcinoma is associated with clinical prognosis |
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| Jianming Zhang,Wei Zhang,Ping Gao,Yanqiu Li,Changyi Li,Sakan Maeda. Expression of E-cadherin in oral squamous cell carcinoma is associated with clinical prognosis[J]. Chinese Journal of Clinical Oncology, 2006, 3(3): 181-184. DOI: 10.1007/s11805-006-0115-z | |
| Authors: | Jianming Zhang Wei Zhang Ping Gao Yanqiu Li Changyi Li Sakan Maeda |
| Affiliation: | 1. Department of Emergency, Stomatology Hospital of Tianjin Medical University,Tianjin 300070, China 2. Tianjin University of Chinese Traditional Medicine, Tianjin 300070, China 3. Division of Molecular Pathology, Kobe University Graduate School of Medicine,Kobe, Japan |
| Abstract: | OBJECTIVE To investigate the correlation of E-cadherin expression with clinicopathological parameters and prognosis of patients with oral squa- mous cell carcinoma. METHODS We examined the expression of the protein E-cadherin in 43 oral squamous cell carcinoma (SCC) surgical speciments by SABC im- munohistochemistry. RESULTS There was a significant correlation between the level of E- cadherin expression and tumor stage (P=0.024), invasive pattern (P= 0.009) and lymph node metastasis (P=0.023). No relation was found with age (P=0.084), sex (P= 1.356) and differentiation (P=0.877). Using the Kaplan-Meier method we demonstrated that those cases which showed E-cadherin expression (-) or ( ) had a significantly poorer prognosis compared those cases which showed expression ( ) or ( ) (P= 0.0146). CONCLUSION E -cadherin, is an important indicator of clinical diag- noses and prognositic marker for oral SCC patients. |
| Keywords: | E-cadherin metastasis prognosis squamous cell carcinoma. |
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