| 脊髓小胶质细胞内信号p38丝裂原活化蛋白激酶在神经病理性疼痛的作用 |
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| 引用本文： | 浦少锋,杜冬萍. 脊髓小胶质细胞内信号p38丝裂原活化蛋白激酶在神经病理性疼痛的作用[J]. 国际麻醉学与复苏杂志, 2009, 30(3). DOI: 10.3760/cma.j.issn.1673-4378.2009.03.026 |
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| 作者姓名： | 浦少锋 杜冬萍 |
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| 作者单位： | 上海交通大学附属第六人民医院麻醉科,200233;上海交通大学附属第六人民医院麻醉科,200233 |
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| 摘 要： | 证据表明小胶质细胞在神经病理性疼痛中扮演着重要的角色.神经损伤后,小胶质细胞内p38丝裂原活化蛋白激酶(p38 mitogen activated protein kinase,p38MAPK)激活,致小胶质细胞产生各种生物活性物质,引发痛觉超敏.小胶质细胞内p38MAPK在神经病理性疼痛的发生和发展中起重要作用,p38MAPK及其亚型有望成为治疗神经病理性疼痛的新靶点.
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| 关 键 词： | 小胶质细胞 p38丝裂原活化蛋白激酶 神经病理性疼痛 |
The effect of microglial signaling p38MAPK on neuropathic pain |
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| PU Shao-feng,DU Dong-ping. The effect of microglial signaling p38MAPK on neuropathic pain[J]. international journal of anesthesiology and resuscitation, 2009, 30(3). DOI: 10.3760/cma.j.issn.1673-4378.2009.03.026 |
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| Authors: | PU Shao-feng DU Dong-ping |
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| Abstract: | Emerging evidences indicate that microglia plays a critical role in the pathogenesis of neuropathic pain. Previous evidences suggest that the activation of p38MAPK signaling pathway in hyperactive microglia in the dorsal horn of spinal cord in-volves in the neuropathic pain. Present findings shows that p38MAPK is activated in the spinal microglia after nerve injury and con-tributes importantly to the development and maintenance of neuropathic pain. |
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| Keywords: | Microglia p38MAPK Neuropathic pain |
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