Degradable particulate composite reinforced with nanofibres for biomedical applications |
| |
| Authors: | E.D. Pinho A. Martins J.V. Araújo R.L. Reis N.M. Neves |
| |
| Affiliation: | 1. Advanced Polymer and Composites (APC) Research Group, University of Portsmouth, School of Engineering, Anglesea Road, Anglesea Building, PO1 3DJ, UK;2. Department of Chemical Engineering Materials Environment, Sapienza-Università di Roma, Via Eudossiana 18, 00184 Roma, Italy;3. School of Architecture and Design, University of Camerino, Viale della Rimembranza, 63100 Ascoli Piceno, Italy;4. Department of Aerospace Engineering, Anna University, Madras Institute of Technology Campus, Chromepet, Chennai 600044, Tamil Nadu, India;1. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4806-909 Caldas das Taipas, Portugal;2. ICVS/3B’s – PT Government Associated Laboratory, Braga/Guimarães, Portugal;3. CeNTI, Centre for Nanotechnology and Smart Materials, V.N. Famalicão, Portugal;4. CITEVE, Technological Centre for Textile and Clothing Industry, V.N. Famalicão, Portugal;5. Department of Health Sciences, Portuguese Catholic University, Viseu, Portugal;1. Dipartimento di Ingegneria Civile, Chimica, Ambientale e dei Materiali, Università di Bologna, Via Terracini 28, 40131 Bologna, Italy;2. Istituto per la Sintesi Organica e la Fotoreattività, CNR, Via Selmi 2, 40126 Bologna, Italy;3. Dipartimento di Ingegneria Industriale, Università di Catania, Viale A. Doria 6, 95125 Catania, Italy;4. Dipartimento di Scienze e Tecnologie Agro-Alimentari, Università di Bologna, Piazza Goidanich, 60, 47521 Cesena, Italy;1. Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, GR-541 24 Thessaloniki, Macedonia, Greece;2. Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany;1. The Key Laboratory of Polymer Processing Engineering of Ministry of Education, South China University of Technology, Guangzhou, 510640, PR China;2. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, PR China;3. Department of Industrial Equipment and Control Engineering, South China University of Technology, Guangzhou, 510640, PR China;4. Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510006, PR China |
| |
| Abstract: | Nanofibre-based structures and their composites are increasingly being studied for many biomedical applications, including tissue engineering scaffolds. These materials enable architectures resembling the extracellular matrix to be obtained. The search for optimized supports and carriers of cells is still a major challenge for the tissue engineering field. The main purpose of this work is to develop a novel composite structure that combines microparticles and nanofibres in reinforced polymeric microfibres. This innovative combination of materials is obtained by melting extrusion of a particulate composite reinforced with chitosan nanofibre meshes (0.05 wt.%) produced by the electrospinning technique. The reinforced microfibres were analysed by scanning electron microscopy and showed a considerable alignment of the chitosan nanofibres along the longitudinal main axis of the microfibre composite structure. The tensile mechanical properties revealed that the introduction of the nanofibre reinforcement in the particulate microfibre composite increased the tensile modulus by up to 70%. The various structures were subjected to swelling and degradation tests immersed in an isotonic saline solution at 37 °C. The presence of chitosan nanofibres in the particulate microfibres enhances the water uptake by up to 24%. The combination of good mechanical properties and enhanced degradability of the developed structures is believed to have great potential for various biomedical applications, including three-dimensional fibre mesh scaffolds to be applied in the field of bone tissue engineering. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
