Enhanced osseointegration of grit-blasted,NaOH-treated and electrochemically hydroxyapatite-coated Ti–6Al–4V implants in rabbits |
| |
| Authors: | Dror Lakstein William Kopelovitch Zahava Barkay Medlej Bahaa David Hendel Noam Eliaz |
| |
| Institution: | 1. Sakarya University, Biomedical, Magnetic and Semiconductor Materials Application & Research Center (BIMAS-RC), 54187, Sakarya, Turkey;2. Sakarya Applied Sciences University, Faculty of Technology, Metallurgical and Materials Engineering Department, 54187, Sakarya, Turkey;3. Marmara University, Faculty of Technology, Metallurgical and Materials Engineering Department, Goztepe, 34722 Istanbul, Turkey;4. Marmara University, Faculty of Art and Sciences, Department of Biology, 34722, Goztepe, Istanbul, Turkey;5. Sakarya University, Science & Arts Faculty, Department of Chemistry, 54187, Sakarya, Turkey;1. Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany;2. Biophysics group, Center for Medical Physics and Technology, University of Erlangen-Nuremberg, Henkestrasse 91, 91052 Erlangen, Germany;3. Institute of Polymer Science, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Martensstr. 7, 91058 Erlangen, Germany;4. Escuela de Ciencia e Ingeniería de los Materiales (ECIM), Costa Rican Institute of Technology (ITCR), Cartago 159-7050, Costa Rica;5. Institute of Surface Science and Corrosion, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Martensstrasse 7, 91058 Erlangen, Germany;6. Faculty of Metals Engineering and Industrial Computer Science, AGH University of Science and Technology, Czarnowiejska 66, 30-054 Kraków, Poland;1. Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan Xi Road, Wenzhou, Zhejiang 325027, China;2. Endocrine & Metabolic Diseases Unit, Affiliated Hospital of Guizhou Medical University, Guizhou 550001, China;3. Department of Orthopaedic Surgery, Hangzhou Bay Hospital of Ningbo, 315000, China;4. Department of Orthopaedic Surgery, Jingmen No. 1 People''s Hospital, Jingmen 44800, Hubei, China;5. Department of Orthopaedic Surgery, Wenzhou Central Hospital, Wenzhou, Zhejiang 325000, China;6. Sichuan Provincial Orthopedics Hospital, No. 132 West First Section First Ring Road, Chengdu, Sichuan 610000, China |
| |
| Abstract: | Osseointegration, in terms of the bone apposition ratio (BAR) and the new bone area (NBA), was measured by backscattered electron imaging. The results were compared for four implant types: grit-blasted and NaOH-treated Ti–6Al–4 V (Uncoated-NaOH), electrodeposited with hydroxyapatite without alkali treatment (ED-HAp), electrodeposited with hydroxyapatite after alkali treatment (NaOH-ED-HAp), and plasma sprayed with hydroxyapatite (PS-HAp). No heat treatment was done after soaking in NaOH. The implants were press fitted into the intramedullary canal of mature New Zealand white rabbits and analyzed, both at the diaphyseal and at the metaphyseal zones, either 1 week or 12 weeks after surgery. NaOH-ED-HAp already exhibited a higher BAR value than the ED-HAp at 1 week, and was as good as the commercial PS-HAp at 12 weeks. The NBA value for NaOH-ED-HAp at 12 weeks was the highest. The higher content of octacalcium phosphate in NaOH-ED-HAp, as evident from the X-ray photoelectron spectroscopy analysis of the oxygen shake-up peaks, and the associated increase in the solubility of this coating in vivo are considered responsible for the enhanced osseointegration. Taking into account also the reduced occurrence of delamination and the inherent advantages of the electrodeposition process, electrodeposition of HAp following soaking in NaOH may become an attractive alternative for the traditional plasma-sprayed process for coating of orthopedic and dental implants. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
