Serotonin Transporter Promoter Region (5-HTTLPR) Polymorphism is Associated with the Intravaginal Ejaculation Latency Time in Dutch Men with Lifelong Premature Ejaculation |
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| Authors: | Paddy K.C. Janssen Steven C. Bakker Janos Réthelyi Aeilko H. Zwinderman Daan J. Touw Berend Olivier Marcel D. Waldinger |
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| Affiliation: | 2. Complex Genetics Section, DBG-Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands;3. Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary;4. Department of Medical Statistics, Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands;5. Apotheek Haagse Ziekenhuizen, The Hague, the Netherlands;11. Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, the Netherlands;1. Health Sciences School, Beira Interior University (FCS-UBI), Covilhã, Portugal;2. the Department of Urology of Pêro da Covilhã Hospital, Cova da Beira Hospital Centre (CHCB), Covilhã, Portugal;1. Santa Clara Valley Medical Center, Santa Clara, CA, USA;2. Glaxo Smith Kline, Research Triangle Park, NC, USA;3. Glaxo Smith Kline, King of Prussia, PA, USA;2. Department of Urology, University of Naples Federico II, Naples, Italy;1. Department of UrologyThe First Affiliated Hospital of Anhui Medical UniversityHefeiAnhuiChina;2. Academy of Public HealthAnhui Medical UniversityHefeiAnhuiChina |
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| Abstract: | IntroductionLifelong premature ejaculation (LPE) is characterized by persistent intravaginal ejaculation latency times (IELTs) of less than 1 minute, and has been postulated as a neurobiological dysfunction with genetic vulnerability for the short IELTs, related to disturbances of central serotonin (5-hydroxytryptamine [5-HT]) neurotransmission and 5-HT receptor functioning.AimTo investigate the relationship between 5-HT transporter gene-linked polymorphism (5-HTTLPR) and short IELTs in men with lifelong PE.MethodsA prospective study was conducted in 89 Dutch Caucasian men with lifelong PE. IELT during coitus was assessed by stopwatch over a 1-month period. Controls consisted of 92 Dutch Caucasian men. All men with LPE were genotyped for a 5-HTT-promoter polymorphism. Allele frequencies and genotypes of short (S) and long (L) variants of 5-HTTLPR polymorphism were compared between patients and controls. Association between LL, SL, and SS genotypes, and the natural logarithm of the IELT in men with LPE was investigated.Main Outcome MeasuresIELT measured by stopwatch, 5-HTTLPR polymorphism.ResultsIn men with lifelong PE, the geometric mean, median, and natural mean IELTs were 21, 26, and 32 seconds, respectively. There were no significant differences in the 5-HTT polymorphism alleles and genotypes between 89 Dutch Caucasian men with LPE (S 47%, L 53%/LL 29%, SL 48%, SS 22%) and 92 Dutch Caucasian controls (S 48%, L 52%/LL 29%, SL 45%, SS 26%). In men with lifelong PE there was a statistically significant difference between LL, SL, and SS genotypes in their geometric mean IELT (P ≤ 0.027); the LL genotypes had significantly shorter IELTs than the SS and SL genotypes.ConclusionsThe 5-HTTLPR polymorphism is associated with significant effects on the latency to ejaculate in men with lifelong PE. Men with SS and SL genotypes have 100% and 90% longer ejaculation time, respectively than men with LL genotypes. Janssen PKC, Bakker SC, Réthelyi J, Zwinderman AH, Touw DJ, Olivier B, and Waldinger MD. Serotonin transporter promoter region (5-HTTLPR) polymorphism is associated with the intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation. |
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