Interindividual variability of drug transporters: Impact on opioid treatment in chronic renal failure |
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| Authors: | Guglielmina Nadia Ranzani Simona De Gregori Manuela De Gregori Mario Regazzi Stefano Govoni |
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| Institution: | 1. Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan;2. RIKEN Center for Molecular Imaging Science, Hyogo, Japan;3. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan;4. Sugiyama Laboratory, RIKEN Innovation Center, Research Cluster for Innovation, RIKEN, Kanagawa, Japan |
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| Abstract: | Some transmembrane transporters influence the absorption, the tissue distribution and the elimination of opioids, and their genetic variants may be an important factor in therapeutic efficacy and toxicity. Uptake and efflux transporters may facilitate or limit access of opioids to blood–brain barrier (BBB), modulating pain relief. As renal function is crucial in the metabolism and pharmacokinetic profile of any drug, renal failure and end-stage renal disease may alter drug disposition by affecting protein and tissue binding, and reducing systemic clearance of drugs. |
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