Biocompatibility of corrosion-resistant zeolite coatings for titanium alloy biomedical implants |
| |
| Authors: | Rajwant S. Bedi Derek E. Beving Laura P. Zanello Yushan Yan |
| |
| Affiliation: | 1. Department of Chemical & Environmental Engineering, University of California, Riverside, CA 92521, USA;2. Department of Biochemistry, University of California, Riverside, CA 92521, USA;1. CIRIMAT, INPT-CNRS-UPS, Université de Toulouse, Université Paul Sabatier, Toulouse, France;2. LPCME, CNRST-URAC 20, Faculté des Sciences Semlalia, University Cadi Ayyad, Marrakech, Morocco;3. School of Science & Engineering, Al Akhawayn University, Ifrane, Morocco;4. Laboratoire de Physique et d’Etude des Matériaux, ESPCI, Paris, France;5. CIRIMAT, INPT-CNRS-UPS, Université de Toulouse, ENSIACET, Toulouse, France;1. Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science & Engineering, Hubei University, Wuhan, China;2. Division of Spine Surgery, Department of Orthopaedics & Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China;3. Center for Human Tissues and Organs Degeneration, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China;10. Department of Endodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran;1. Department of Dental Materials and Prosthesis, School of Dentistry of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, SP, Brazil;2. Department of Materials Engineering, Federal University of São Carlos (UFSCAR), São Carlos, SP, Brazil |
| |
| Abstract: | Titanium alloy, Ti6Al4V, is widely used in dental and orthopedic implants. Despite its excellent biocompatibility, Ti6Al4V releases toxic Al and V ions into the surrounding tissue after implantation. In addition, the elastic modulus of Ti6Al4V (～110 GPa) is significantly higher than that of bone (10–40 GPa), leading to a modulus mismatch and consequently implant loosening and deosteointegration. Zeolite coatings are proposed to prevent the release of the toxic ions into human tissue and enhance osteointegration by matching the mechanical properties of bone. Zeolite MFI coatings are successfully synthesized on commercially pure titanium and Ti6Al4V for the first time. The coating shows excellent adhesion by incorporating titanium from the substrate within the zeolite framework. Higher corrosion resistance than the bare titanium alloy is observed in 0.856 M NaCl solution at pHs of 7.0 and 1.0. Zeolite coatings eliminate the release of cytotoxic Al and V ions over a 7 day period. Pluripotent mouse embryonic stem cells show higher adhesion and cell proliferation on the three-dimensional zeolite microstructure surface compared with a two-dimensional glass surface, indicating that the zeolite coatings are highly biocompatible. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
