Functionalized poly(lactic-co-glycolic acid) enhances drug delivery and provides chemical moieties for surface engineering while preserving biocompatibility |
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| Authors: | James P. Bertram Steven M. Jay Sara R. Hynes Rebecca Robinson Jason M. Criscione Erin B. Lavik |
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| Affiliation: | 1. Institute of Biophysics and Radiation Biology, Semmelweis University, 1444 Budapest POB 263, Hungary;2. Research Group of Peptide Chemistry, Hungarian Academy of Sciences, Eötvös Loránd University, Pázmány Péter sétány 1/A, Budapest H-1117, Hungary;3. Institute of Chemistry, University of Silesia, Katowice 40-006, Poland;4. Laboratory of Chiroptical Structure Analysis, Institute of Chemistry, Eötvös Loránd University, Pázmány Péter sétány 1/A, Budapest H-1117 Hungary;5. Department of Plant Physiology and Biochemistry, Jagiellonian University, ul. Gronostajowa 7, Kraków 30-387, Poland;6. Biophysik der Makromoleküle, DKFZ, Neuenheimer Feld 280, D-69120 Heidelberg, Germany;1. Department of Physics and Biophysics, Wroc?aw University of Environmental and Life Sciences, ul. Norwida 25, 50-375 Wroc?aw, Poland;2. Organic and Pharmaceutical Technology Group, Faculty of Chemistry, Wroc?aw University of Technology, Wybrze?e Wyspiańskiego 27, 50-370 Wroc?aw, Poland;3. J. Heyrovsky Institute of Physical Chemistry of the ASCR, v.v.i., Dolej?kova 2155/3, 182 23 Prague 8, Czech Republic |
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| Abstract: | Poly(lactic-co-glycolic acid) (PLGA) is one of the more widely used polymers for biomedical applications. Nonetheless, PLGA lacks chemical moieties that facilitate cellular interactions and surface chemistries. Furthermore, incorporation of hydrophilic molecules is often problematic. The integration of polymer functionalities would afford the opportunity to alter device characteristics, thereby enabling control over drug interactions, conjugations and cellular phenomena. In an effort to introduce amine functionalities and improve polymer versatility, we synthesized two block copolymers (PLGA-PLL 502H and PLGA-PLL 503H) composed of PLGA and poly(ε-carbobenzoxy-l-lysine) utilizing dicyclohexyl carbodiimide coupling. PLGA-PLL microspheres encapsulated approximately sixfold (502H) and threefold (503H) more vascular endothelial growth factor, and 41% (503H) more ciliary neurotrophic factor than their PLGA counterparts. While the amine functionalities were amenable to the delivery of large molecules and surface conjugations, they did not compromise polymer biocompatibility. With the versatile combination of properties, biocompatibility and ease of synthesis, these block copolymers have the potential for diverse utility in the fields of drug delivery and tissue engineering. |
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