Porous titanium and silicon-substituted hydroxyapatite biomodification prepared by a biomimetic process: Characterization and in vivo evaluation |
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| Authors: | Erlin Zhang Chunming Zou |
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| Institution: | 1. Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016, People’s Republic of China;2. School of Materials Science and Engineering, Jiamusi University, Jiamusi 154007, People’s Republic of China;3. School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, People’s Republic of China;1. Ecole Nationale Supérieure des Mines de Saint-Etienne, CIS-EMSE, CNRS:FRE3312, 158 Cours Fauriel, F-42023 Saint-Etienne Cedex 2, France;2. Institut des Matériaux de Paris Centre, FR 2482, Université Pierre et Marie Curie et CNRS, Collège de France, 11 Place Marcelin Berthelot, 75005 Paris, France;3. Université de Lyon, INSA-Lyon, MATEIS Laboratory UMR CNRS 5510, F-69621 Villeurbanne, France;4. Laboratoire de Chimie de la Matière Condensée de Paris, Université Pierre et Marie Curie et CNRS, Collège de France, 11 Place Marcelin Berthelot, 75005 Paris, France;1. Advanced Institute for Science and Technology (AIST), Hanoi University of Science and Technology (HUST), No. 01, Dai Co Viet Road, Hanoi, Vietnam;2. School of Engineering Physics, Hanoi University of Science and Technology (HUST), No. 01, Dai Co Viet Road, Hanoi, Vietnam;1. Department of Materials Science and Engineering, University of Sheffield, Sir Robert Hadfield Building, Mappin St, Sheffield S1 3JD, UK;2. Kroto Research Institute, University of Sheffield, Broad Lane, Sheffield S3 7HQ, UK;3. Insigneo Institute for in silico Medicine, University of Sheffield, Pam Liversidge Building, Mappin St, Sheffield S1 3JD, UK;4. Department of Prosthodontic, College of Dentistry, University of Kufa, Najaf, Iraq;5. Medical Advanced Manufacturing Research Centre (AMRC), Wallis Way, Catcliffe, Rotherham S60 5TZ, UK;6. Materials a?n?d? Engineering Research Institute, Sheffield Hallam University, Sheffield S1 1WB, UK;1. Department of Metallurgy and Materials Engineering (MTM), KU Leuven, Kasteelpark Arenberg 44 – bus 2450, B-3001 Heverlee, Belgium;2. Department of Oral Health Sciences, BIOMAT Research Group, KU Leuven, Kapucijnenvoer 7 blok a – bus 7001, B-3000 Leuven, Belgium;1. Research Institute for Applied Mechanics, Kyushu University, Kasuga, Fukuoka 816-8580, Japan;2. Department of Animal Husbandry and Veterinary Science, University of Rajshahi, Rajshahi 6205, Bangladesh |
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| Abstract: | Porous titanium with a pore size of 150–600 μm and a porosity of 67% was prepared by fiber sintering. The porous titanium had a complete three-dimensional (3D) interconnected structure and a high yield strength of 100 MPa. Si-substituted hydroxyapatite (Si-HA) was coated on the surface by a biomimetic process to improve the surface bioactivity. X-ray diffraction results showed that Si-HA coating was not well crystallized. New bone tissue was found in the uncoated porous titanium after 2 weeks of implantation and a significant increase (p < 0.05) in the bone ingrowth rate (BIR) was found after 4 weeks of implantation, indicating the good osteoconductivity of the porous structure. The HA-coated and Si-HA-coated porous titanium exhibited a significantly higher BIR than the uncoated titanium at all intervals, highlighting the better surface bioactivity and osteoconductivity of the HA- and Si-HA coatings. Also, the Si-HA-coated porous titanium demonstrated a significantly higher BIR than the HA-coated porous titanium, showing that silicon plays an active role in the surface bioactivity. For Si-HA-coated porous titanium, up to 90% pore area was covered by new bone tissue after 4 weeks of implantation in cortical bone. In the bone marrow cavity, the pore spaces were filled with bone marrow, displaying that the interconnected pore structure could provide a channel for body fluid. It was concluded that both the 3D interconnected pore structure and the Si-HA coating contributed to the high BIR. |
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