生物材料血液相容性体外评价的研究进展

目前主要采用体外、半体内以及体内实验对生物材料的血液相容性进行评价。体外实验由于快速、经济等特点,在生物材料血液相容性初步筛选实验中得到了广泛应用。生物材料的表面化学性质、总面积以及表面纹理等特性均会对其血液相容性产生影响。因此,生物材料体外血液相容性评价存在与生物材料研发的各个环节。高效、快速、准确的生物材料血液相容性评价方法有助于缩短生物材料研发周期。因此,近些年很多专家学者关于生物材料血液相容性体外评价开展了大量研究工作,并取得了一系列研究成果。文章将这些新进展和新认识进行综合,以期为生物材料血液相容性研究工作的开展提供借鉴。

The Research Progress of Biomaterial Blood Compatibility Evaluation in Vitro

At present, the blood compatibility of biological materials is evaluated mainly in vitro, in vivo and in vivo experiments. In vitro experiments have been widely used in the preliminary screening experiments of biomaterials blood compatibility due to their rapid and economical characteristics. Properties such as surface chemistry, total area, and surface texture of biological materials have an effect on their blood compatibility. Therefore, the evaluation of in vitro blood compatibility of biological materials exists in all aspects of the development of biological materials. Efficient, fast, and accurate blood material compatibility assessment methods for biomaterials help to shorten the biomaterial development cycle. Therefore, in recent years, many experts and scholars have carried out a lot of research work on the in vitro evaluation of blood compatibility of biological materials, and have obtained a series of research results. This paper synthesizes these new developments and new understandings in order to provide reference for the development of biomaterials blood compatibility research.