Antibiotic-eluting bioresorbable composite fibers for wound healing applications: Microstructure,drug delivery and mechanical properties |
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| Authors: | Jonathan J. Elsner Meital Zilberman |
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| Affiliation: | 1. Departamento de Química de Radiaciones y Radioquímica, Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510 México, D.F., Mexico;2. Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain;3. Departamento de Microbiología y Parasitología, Facultad de Biología CIBUS, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain;1. Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy;2. Department of Pharmacy and Pharmaceutical Technology, University of Granada, Campus of Cartuja, Granada, 18071 s/n, Spain;3. Andalusian Institute of Earth Sciences, CSIC-University of Granada, Armilla, Granada, Spain;1. CICS-UBI – Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal;2. UDI-IPG- Unidade de Investigação para o Desenvolvimento do Interior, Instituto Politécnico da Guarda, 6300-559 Guarda, Portugal;3. Departamento de Química, Universidade da Beira Interior, R. Marquês d’Ávila e Bolama, 6201-001 Covilhã, Portugal;4. CIEPQPF – Departamento de Engenharia Química, Universidade de Coimbra, Rua Sílvio Lima, 3030-790 Coimbra, Portugal;1. Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna Hermosillo # 140, 25294, Saltillo, Coahuila, Mexico;2. CONACyT–Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna Hermosillo # 140, 25294, Saltillo, Coahuila, Mexico;1. School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China;2. School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China;3. Caritas Institute of Higher Education, China |
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| Abstract: | Novel antibiotic-eluting composite fibers designed for use as basic wound dressing elements were developed and studied. These structures were composed of a polyglyconate core and a porous poly(dl-lactic-co-glycolic acid) shell loaded with one of three antibiotic drugs: mafenide acetate, gentamicin sulphate and ceftazidime pentahydrate. The shell was prepared by the freeze-drying of inverted emulsions. The fiber investigation focused on the effects of the emulsion’s formulation on the shell microstructure and on the resulting profile of drug release from the fibers. Albumin was found to be the most effective surfactant for stabilizing the inverted emulsions and also to have a beneficial holdup effect on the release kinetics of the hydrophilic antibiotic drugs, especially mafenide acetate, probably through a specific interaction. An increase in the organic:aqueous phase ratio, polymer content or molecular weight of the host polymer resulted in a decrease in the burst release and a more moderate release profile due to changes in shell microstructure. The first two parameters were found to be more effective than the third. The diverse release profiles obtained in the current study and the good mechanical properties indicate that our new composite fibers have good potential for use in wound healing applications. |
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