帕金森病患者智能损害及其危险因素探讨

目的了解帕金森病(PD)患者的智能损害的发生率及其造成智能损害的危险因素。方法36例PD患者的MMSE分值作为因变量,性别、年龄、病程、发病年龄、静止性震颤、强直、运动减少及病情分级作为自变量进行多元回归分析。结果PD患者智能损害的发生率为27.78%,其MMSE分值明显低于对照组(P<0.001);其MMSE分值与受教育程度呈正相关,与发病年龄和病情分级呈负相关。结论PD患者存在明显的智能损害,受教育的程度、发病的年龄和病情的严重程度可能是预测PD患者智能损害的危险因素之一。

A study on the intellectual impairment and risk factor in patients with Parkinson disease

Objective In order to find the incidence rate of intellectual impairment and risk factor in patients with Parkinson disease(PD).Methods 36 patients with PD were analyzed by using MMSE; Multiple regression analysis was measured when MMSE scores were used as dependent variance and sex,age,course,age at onset of PD,resting tremor,bradykinesia,rigidity and Hoehn yahr scores were used as independent variance. Results The incidence rate of intellectual impairment in patients with PD was 27.78% and MMSE scores of them were lower markedly than that of control group (P< 0.001).There was a positive relation between the MMSE scores and the educational levels and there was a negative relation between the MMSE scores and age at onset of PD or Hoehn Yahr scores in patients with PD.Conclusions Patients with PD have marked intellectual impairment,The educational levels and age at onset of PD and the severity of cases(Hoehn yahr scores) in patient with PD were risk factors to intellectual impairment.