| 用基因芯片研究不同皮肤组织创面愈合过程中同源异形框基因的差异表达 |
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| 引用本文： | 宋慧锋,柴家科,陈敏亮,林子豪.用基因芯片研究不同皮肤组织创面愈合过程中同源异形框基因的差异表达[J].中华整形外科杂志,2005,21(5):372-374. |
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| 作者姓名： | 宋慧锋 柴家科 陈敏亮 林子豪 |
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| 作者单位： | 1. 100037,北京,解放军总医院304临床部烧伤整形外科,全军烧伤研究所
2. 第二军医大学附属长征医院整形外科 |
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| 基金项目： | 国家自然科学基金（编号：30000174）;中国博士后科研基金（编号：2004035075） |
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| 摘 要： | 目的 探讨人胎儿及成人皮肤创面愈合过程中同源异形框基因的差异表达.方法 采用包含有14000个靶基因cDNA克隆的基因芯片技术,对正常成人和胎儿及其创面愈合过程中同源异形框基因族的表达进行对比观察.结果 正常成人和胎儿及其创面愈合过程中同源异形框基因族呈现差异表达,其中以PRX-2、HOXB13、HOXB6和HOXB7的差异表达为显著.结论 同源异形框基因的差异表达表明正常成人和胎儿皮肤的发育生物学状态存在差异,可能是胎儿和成人皮肤不同创面愈合方式的根本原因.
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| 关 键 词： | 同源异形框基因 胎儿 皮肤 创面愈合 基因芯片 同源异形框基因 皮肤组织创面 基因芯片技术 差异表达 愈合过程 cDNA克隆 发育生物学 人胎儿 皮肤创面 |
| 收稿时间： | 2004-11-11 |
| 修稿时间： | 2004年11月11 |
Differential display of homeobox gene expressions in the normal, wounded human fetal and adult skins by DNA microarray |
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| SONG Hui-feng,CHAI Jia-ke,CHEN Min-liang,LIN Zi-hao.Differential display of homeobox gene expressions in the normal, wounded human fetal and adult skins by DNA microarray[J].Chinese Journal of Plastic Surgery,2005,21(5):372-374. |
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| Authors: | SONG Hui-feng CHAI Jia-ke CHEN Min-liang LIN Zi-hao |
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| Institution: | Department of Burros and Plastic Surgery, Burn Institute, the 304th Hospital Affiliated to PLA General Hospital, Beijing 100037, China |
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| Abstract: | Objective To explore the differential expression of homeobox genes in the normal , wounded human fetal and aduh skins and its significance in fetal scarless healing. Methods Gene chips containing 14 000 human genes were used to investigate homeobox gene expressions of the normal, wounded human fetal and adult skins. Results There were significant differences between the expression of homeohox genes, especially for PRX-2, HOXB13, HOXB6 and HOXB7. Conclusions The homeobox gene is in close relation to developmental hiology. The different expressions and changes of homeohox genes in the normal, wounded human fetal and adult skin may be a primal cause of different wound healing between fetal and aduh skin. |
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| Keywords: | Homeobnx genes Fetal Skin Wound healing DNA mieroarray |
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