急性胰腺炎时血小板、抗凝血系统功能状态的变化

目的：探讨血小板的活化释放功能和抗凝血系统功能，在观察重症急性胰腺炎病程发展变化的临床价值。方法：测定血浆β－血小板球蛋白、血小板第4因子、血栓素B2、血小板颗粒膜蛋白、血浆5－羟色胺、抗凝血酶－Ⅲ抗原脑海在性、蛋白C抗原及活性等指标。结果：急性水肿型胰腺炎各项指标均与对照组间无显著性差异（P＞0．05），急性出血坏死型胰腺炎血小板各项指标均高于对照组（P＜0．01），抗凝血系统各项指标均低于对照组（P＜0．01）。结论：急性出血坏死型胰腺炎血小板功能被激活，抗凝血系统水平和活性低下，测定这些指标对了解病程发展和预防并发症具有一定意义。

Changes of the Function of Platelet and Anticoagulation in Patients with Acute Pancreatitis

Objective:To investigate the clinical value of changes of platelet and anticoagulation function in patients with acute pancreatitis. Methods:β-TG, PF4 ,TXB2 ,GMP-140,antithrombin-Ⅲ,and protein C were measured in all patients. Results:There was no significant difference in all parameters between acute edema pancreatitis group and normal group(P＞0.05).Compared with the control group, parameters of platelet significantly increased in acute necrosis pancreatitis group(P＜0.01),and parameters of anticoagulation significantly decreased(P＜0.01). Conclusion: The platelet system was activated and the level of anticoagulation system decreased in acute necrosis pancreatitis. Parameters are important in understanding and preventing this disease.