新生儿ABO溶血病患儿母亲孕期IgG抗A/B效价的动态监测

目的动态监测O型孕妇不同孕期血清IgG抗A/B效价,为更加准确地预测新生儿ABO溶血病的发生提供诊断依据。方法通过对232例新生儿ABO溶血病的患儿母亲孕早期和孕晚期IgG抗A/B效价的动态监测,观察这类孕妇抗体效价的分布情况、变化率和变化幅度。结果这类孕妇的孕早期和孕晚期IgG抗A/B效价大多分布在≥1∶256,其中绝大多数孕妇（O-A：94.9%,O-B：95.8%）孕晚期的IgG抗A/B效价较孕早期有不同程度的升高;以升高2个滴度为主（O-A：46.3%,O-B：44.8%）。有11例其孕晚期的IgG抗A/B效价较孕早期无变化甚至发生降低,这11例孕妇孕早期的IgG抗A/B效价就偏高,主要分布在≥1∶512。结论动态监测O型孕妇不同孕期血清IgG抗A/B效价十分必要,可以将孕晚期抗体效价较孕早期升高2个滴度或以上作为提示ABO溶血的指标。

The dynamic monitoring of the serum lgG anti-A/B titer of pregnant women for predicting if their newborn children attack with ABO hemolytic disease

Objective To monitor dynamically the serum IgG anti-A/B titer of O blood group pregnant women in different stages of gestation,and provide diagnosis evidence for predicting the occurrence of neonatal ABO hemolytic disease.Methods Through dynamically monitoring of 232 cases of IgG anti-A/B titer of ABO hemolytic disease of newborn children′s pregnant women in first trimester and third trimester,the distribution of antibody titers,the rate of change and changing amplitude were observed.Results The distribution of IgG anti-A/B titer in first trimester and third trimester was ≥1∶ 256.In most of O blood group pregnant women,the IgG anti-A/B titer in third trimester increased in varying degree by comparing the IgG anti-A/B titer in first trimester（O-A： 94.9%,O-B： 95.8%）.Most of them increased 2 of titer（O-A：46.3%,O-B：44.8%）.There were 11 cases that the IgG anti-A/B titer in third trimester did not change or decreased,since these 11 cases had higher IgG anti-A/B titer in first trimester,and the distribution was ≥1∶ 512.Conclusions It is necessary to do dynamic monitoring of the serum IgG anti-A/B titer of O blood group pregnant women in different stages of gestation,and the antibody titer in third trimester reaching 2 of titer or more than that in first trimester can be a more accurate evidence for predicting the occurrence of ABO hemolytic disease.