肝损伤酶活性联合检测在肝胆疾病诊断中的相关分析

目的探讨肝损伤酶活性联合检测在肝胆疾病诊断中的临床意义。方法对健康对照组36例和各类肝胆疾病组204例患者的丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、乳酸脱氢酶、腺苷脱氨酶、线粒体天门冬氨酸转氨酶、碱性磷酸酶、γ-谷氨酰转移酶、5′-核苷酸酶活性进行测定与分析。结果肝胆疾病组丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、乳酸脱氢酶、腺苷脱氨酶、线粒体天门冬氨酸转氨酶、碱性磷酸酶、γ-谷氨酰转移酶、5′-核苷酸酶活性均高于健康对照组（P〈0．01）。结论肝损伤酶活性联合检测有利于肝胆疾病的鉴别诊断及疗效观察。

Clinical value of combined detection of hepatic enzymes in diagnosis of liver and gall diseases

Objective To study the diagnostic value of combined detection of hepatic enzymes in diagnosis of liver and gall diseases. Methods The activities of hepatic enzymes （alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, adenosine deaminase, mitochondrial aspartate aminotransferase, alkaline phosphatase, gamma glutamate transpeptidase, 5′-nucleotidase） were measured and analyzed for 36 healthy controls （healthy control group） and 204 patients with different liver and gall diseases （liver and gall disease group）. Results The activities of hepatic enzymes （alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, adenosine deaminase, mitochondrial aspartate aminotransferase, alkaline phosphatase, gamma glutamate transpeptidase, 5′-nucleotidase） were all significantly higher in liver and gall disease group than those of healthy control group （P〈0. 01）. Conclusion The combined detection of hepatic enzymes contributes to the differential diagnosis and therapeutic effect monitoring of liver and gall diseases.