左乙拉西坦对自发性癫痫大鼠大发作和小发作的作用(英文)

目的　鉴于左乙拉西坦在各种啮齿类动物上的抗癫痫作用不同 ,未见报告其在自发性癫痫大鼠上的作用 ,故研究之。方法　在大脑海马和皮质部位安置电极 ,观察腹腔注射单剂量左乙拉西坦对自发性癫痫大鼠脑电图的影响。结果　给左乙拉西坦(40 ,80和 16 0mg·kg- 1,ip)后 135～ 16 5min ,癫痫小发作的总持续时间分别下降到给药前水平的 (87±15 ) % ,(34± 7) %和 (39± 19) %。大发作的总持续时间下降到 (81± 2 8) % ,(6 5± 11) %和 (5 2± 7) %。大发作的出现频率下降到 (71± 2 9) % ,(5 4± 12 ) %和 (32± 15 ) %。结论　左乙拉西坦具有明显的对抗自发性癫痫大鼠的大发作和小发作的作用

Effects of levetiracetam on absence-like seizures and tonic convulsion in spontaneously epileptic rats

AIM In view of the difference of the effects of levetiracetam (Lev) in different rodent models and there is no report on its effects in spontaneously epileptic rats (SER), the effects were studied. METHODS Electrocorticogram and depth electroencephalographic activity in hippocampus of SER were recorded with implanted electrodes after acute intraperitoneally administration of Lev. RESULTS The total duration of absence-like seizures was significantly reduced from 100% to (87±15)%, (34±7)% and (39±19)% by single dose Lev (40, 80 and 160 mg·kg-1, ip), respectively, at 135-165 min after administration. The frequency of tonic convulsion was reduced from 100% to (71±29)%, (54±12)% and (32±15)%. The total duration of tonic convulsion was also reduced to (81±28)%, (65±11)% and (52±7)%, respectively. CONCLUSION Lev is effective for treatment of absence-like seizures and tonic convulsion on SER.